Spolne razlike u osteotropnim elementima u ljudskoj kosi i krvi

doctoral thesis

• Title (english): Gender dependent differences in osteotrophic elements in human hair and blood
• Author: Juraj Prejac
• Mentor: Ninoslav Mimica (mentor)
• Mentor: Berislav Momčilović (komentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2018-02-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Promjene u metabolizmu vezane uz dob i spol, javno su zdravstveni i klinički
problem. Potrebni su pouzdani bioindikatori za individualnu procjenu metaboličkog
statusa bioelemenata, a krv i kosa lako su dostupna tkiva prikladna za određivanje
metaboličkog statusa bioelementnih profila osteotropnih elemenata.
U istraživanje multi-bioelementnog profila osteotropnih elemenata bila su
uključena 192 ispitanika (83 muškarca, 109 žena). Uzorci su analizirani metodom
ICP-MS i izdvojeni su oni bioelementi sa ulogom u metabolizmu kosti: B, Ba, Ca, Mg,
P, Si, Sr i Zn. Analiza nakupljanja bioelemenata u kosi i krvi
(Ca>Zn>P>Mg>Si>Sr>B>Ba) pokazala je da je njihova koncentracija značajno viša u
kosi nego u krvi. To kosu čini pogodnijom organsko-biološkom matricom od krvi za
kemijsku analizu bioelemenata.
Analizirajući frekvenciju distribucije metodom derivata medijana, po prvi puta
su jasno definirani adekvatni rasponi koncentracije bioelemenata u kosi i punoj krvi.
Istodobno, precizirane su i granično niske koncentracije ispitanih bioelemenata ispod
kojih govorimo o deficitu, kao i povišenim vrijednostima kada govorimo o
prekomjernoj izloženosti nekom elementu.
Osobito značajnim smatramo nalaz povišenih koncentracija elemenata
skupine 2A Periodičkog sustava (Ca>Mg>Sr>Ba) u kosi žena naspram kose
muškaraca. Pri tomu je njihov omjer unutar istoga spola bio konstantan. Očigledno je
kako je metabolička kontrola mineralizacije organske biološke matrice kose bitno
različita između muškaraca i žena. Analizom elemenata u krvi, nismo opazili takve
razlike.

Abstract (english)

Metabolic changes related to age and gender are becoming a public health
and clinical problem. Reliable bioindicators for individual assessment of bioelement
metabolic status are needed. Blood and hair are two easily accessible tissues
suitable for metabolic status assesment.
The study included 192 subjects (83 men, 109 women). The samples were
analyzed with the ICP-MS highlighting the osteotrophic elements (B, Ba, Ca, Mg, P,
Si, Sr, and Zn) as the primary research objectives. The accumulation of bioelements
(Ca>Zn>P>Mg>Si>Sr>B>Ba) appeared significantly higher in the hair than the blood.
This fact makes hair a more suitable biological matrix for chemical analysis of the
studied elements than whole blood.
For the first time the normal concentration ranges of bioelements were defined
by analyzing the frequency distribution properties in the hair and whole blood. At the
same time, the concentration limits for bioelement deficiency and excess were
defined.
Especially significant is the finding of higher concentrations of elements
belonging to the 2A group of the Periodic table of elements (Ca>Mg>Sr>Ba) in
women's hair compared to men's. The ratio of osteotrophic bioelements within the
same gender remained unchanged. Evidently, the metabolic control of mineralization
of the organic biological matrix differs substantially between the genders. No such
differences were observed in the whole blood.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:813903
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 208 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:17:55