Scintigrafija somatostatinskih receptora pomoću oktreotida obilježenoga Tehnecijem-99m u bolesnika s neuroendokrinim tumorima

doctoral thesis

• Title (english): Somatostatin receptor scintigraphy in neuroendocrine tumour patients using Technetium-99m octreotide
• Author: Mate Trogrlić
• Mentor: Stanko Težak (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2017-11-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Cilj: ove studije je bila evaluacija dodatne vrijednosti tehnecij-99m oktreotid SPECT/CT-a u odnosu na planarne scintigrame cijelog tijela (WB) i sam SPECT u detekciji i točnoj lokalizaciji lezija neuroendokrinih tumora.
Metode:Ovo istraživanje je obuhvaćalo 65 bolesnika s patohistološki utvrđenom dijagnozom neurondokrinog tumora. Planarni scintigrami cijelog tijela, SPECT i SPECT/CT su snimljeni 4 sata nakon injiciranja 670MBq tehnecij-99m obilježenog oktreotida. Također su snimljeni i dodatni tomogrami (SPECT) 10 minuta po injiciranju radiofarmaka. Kliničko praćenje i praćenje konvencionalnim dijagnostičkim metodama je smatrano referentnim standardom.
Rezultati: Osjetljivost SPECT/CT je iznosila 88.9%, a specifičnost 79.3%. Dijagnostička točnost planarnih scintigrama cijelog tijela iznosila je 72.3%, SPECT snimanja 73.8%, a SPECT/CT snimanja 84.6%. AUC vrijednost („area under curve“) je bila najviša za SPECT/CT (0.84), slijedilo je SPECT snimanje (0.75) te planarni scintigrami cijelog tijela (0.74). Dijagnostička točnost i AUC vrijednost su značajno bolje za SPECT/CT u odnosu na ostale ispitivane modalitete.
Zaključak: Osjetljivost i dijagnostička točnost SPECT/CT u evaluaciji neuroendokrinih lezija je viša u odnosu na ostale ispitivane dijgnostičke modalitete.

Abstract (english)

Objective: The aim of this study was to evaluate the additional value of 99mTc-HYNIC-TOC SPECT/CT over planar whole-body (WB) scintigraphy and SPECT alone in the detection and accurate localisation of neuroendocrine tumour (NET) lesions.
Methods: This study included 65 patients with a definitive histological diagnosis of NET prior to scintigraphy. Planar WB scintigraphy, SPECT, and SPECT/CT images were acquired at 4 h post-administration of 670 MBq 99mTc-HYNIC-TOC. Additional SPECT images at 10 min after tracer administration were also acquired. Clinical and imaging follow-up findings were considered as the reference standards.
Results: The sensitivity and specificity of SPECT/CT were found to be 88.9% and 79.3%, respectively. The diagnostic accuracies of WB scintigraphy, 4h-SPECT, and SPECT/CT were 72.3, 73.8, and 84.6%, respectively. The area under curve (AUC) value for SPECT/CT (0.84) was the highest, followed by those for 4h-SPECT (0.75) and WB scintigraphy (0.74). The accuracy and AUC values of SPECT/CT were significantly better compared to those of WB scintigraphy (P < 0.001), 10 min-SPECT (P < 0.001), and 4h-SPECT (P = 0.001).
Conclusion: The sensitivity and diagnostic accuracy of SPECT/CT in the evaluation of NET lesions are higher compared to those of other tested imaging modalities.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:643888
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 95 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:21:32