Title Mikrobiota voli polifenole Title (english) Microbiota likes polyphenols Author Ana Marija Mandurić Mentor Donatella Verbanac (mentor)Committee member Željko Krznarić (predsjednik povjerenstva)Committee member Jasenka Markeljević (član povjerenstva)Committee member Donatella Verbanac (član povjerenstva)Granter University of Zagreb Defense date and country 2014-07-15, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Crijevna mikrobiota je naziv za skup organizama koji koloniziraju probavni trakt koju čine anaerobne bakterije, 90%, dok se 10% odnosi na ostale eukariotske organizme (gljivice). Prema tri osnovna simbiotička stanja ravnoteže mikrobiote i domaćina određena su tri osnovna tipa sastava mikrobiote koji se nazivaju Enterotipovima koji nisu strogo odvojeni . Učinci koje ona polučuje mogu se podijeliti na metaboličke i imunološke. Polifenoli su grupa spojeva prirodnih, sintetskih i semisintetskih organskih kemikalija koje sadrže veliki broja fenolnih strukturnih jedinica. Oni su sekundarni metaboliti biljaka u kojima imaju višestruku ulogu ,te su nađeni u nekim insektima i rakovima a poznata je njihova uporaba kao boje u tekstilnoj i prehrambenoj industriji. Pripisuju im se antikancerogena, antiteratogena, protuupalna, antimikrobna, antialergijska i mnoga druga svojstva. Određene doze nekih polifenola mogu modificirati sastav mikrobiote tako da potiču ili inhibiraju rast određenih bakterija. Disbioza ili disbalans crijevne mikroflore je pojam koji označava narušavanja prirodne ravnoteže mikroorganizama u probavnom traktu. Specifične disbioze su povezane s pretilim osobama, pacijentima koji boluju od diabetesa tip 2, adolescentima s visokim rizikom za diabetes tip 1, sindromom iritabilnog kolona, upalnim bolestima crijeva, proljev povezan s Clostridium difficile, kolorektalnim karcinomom. Danas sve više istražuju i uvode u kliničku praksu nutritivne sastavnice poput probiotika, prebiotika, simbiotika. Široki spektar pozitivnih učinaka otvaraju mogućnosti snižavanja rizika za neke kronične bolesti konzumacijom namirnica bogatih polifenolima. Zasada se najviše istraživanja provodi s kvercetinom, resverastrolom, katehinima i flavonima iz čaja, kurkuminom, rutinom i sojom. Probioti su pripravci živih mikroorganizama koji imaju pozitivne učinke na domaćina poboljšavajući mu ravnotežu crijevne mikroflore, ojačavajući crijevnu barijeru i poboljšavajući lokalni imunološki odgovor. Mehanizam djelovanja je zasad još nije potpuno jasan, usprkos tome zbog direknog efekta na cijeljenje mukoze probiotici postaju opcija u terapiji.
Abstract (english) The gut microbiota is the name given to the microbe population that colonize the digestive tract consisting of anaerobic bacteria, 90% and 10% related to other eukaryotic organisms (fungi). According to three basic well balanced states between the microbiota and the host there are determined three basic types of microbiota composition called Enterotypes which are not strictly separated. The effects that gut microbiota produces can be divided into metabolic and immunological. Polyphenols are a structural class of natural, synthetic and semi synthetic, organic chemicals characterized by the presence of large multiples of phenol structural units. They are secondary metabolites of plants in which they have multiple roles, and found in some insects and crustaceans and are known for there use as a color in the textile and food industries. Thir attributes are associated to anti-carcinogenic, anti teratogenic, anti inflammatory, antimicrobial, antiallergic and many other effects. Certain doses of some polyphenols may modify the microbiota composition by stimulating or inhibiting the growth of certain bacteria. Intestinal dysbiosis or microbial imbalance refers to disruption of the natural balance of microorganisms in the digestive tract. Specific dysbiosis are associated with obese people, patients suffering from type 2 diabetes, adolescents with high risk for type 1 diabetes, irritable bowel syndrome, inflammatory bowel disease, diarrhea associated with Clostridium difficile, colorectal carcinoma. Today nutritional components such as probiotics, prebiotics, symbiotics are more and more explored and introduced into clinical pratice. A wide range of positive effects are opening up the possibilities of lowering the risk of some chronic diseases by consuming foods rich in polyphenols. So far, most research is conducted with quercetin, resveratrol, catechins and flavones from tea, curcumin, rutin and soybeans. Probiotics are preparations of living microorganisms that have beneficial effects on the host by improving its intestinal microflora balance, strengthening the intestinal barrier and enhancing the local immune response. The mechanism of action is not yet completely clear, despite that because of their direct effect on mucosal healing probiotics are becoming an option in therapy.
Keywords
mikrobiota
polifenoli
disbioza
probiotici
Keywords (english)
microbiota
poliphenols
dybiosis
probiotics
Language croatian URN:NBN urn:nbn:hr:105:094435 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2015-10-02 11:54:15
