Trombocitopenija u trudnoći

master's thesis

• Title (english): Thrombocytopenia in pregnancy
• Author: Andrea Karin
• Mentor: Vesna Elveđi Gašparović (mentor)
• Committee member: Tomislav Čanić (predsjednik povjerenstva)
• Committee member: Dinka Pavičić-Baldani (član povjerenstva)
• Committee member: Vesna Elveđi Gašparović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Trombocitopenija pogađa 6 do 10% trudnoća i druga je po učestalosti hematoloških bolesti u trudnoći. Trombocitopenija označava broj trombocita u krvi manji od 150 x 109/L. Postoji mnogo potencijalnih uzročnika trombocitopenije u trudnoći od kojih su neki specifični za trudnoću, a ostali imaju povećanu incidenciju za vrijeme trudnoće. Trombocitopenija se u trudnoći može pojaviti kao izolirani poremećaj ili u sklopu nekih drugih bolesti. Najčešći izolirani oblik trombocitopenije u trudnoći je gestacijska trombocitopenija s udjelom od najmanje 75%, čiji klinički simptomi nestaju, a laboratorijski nalazi se normaliziraju dovršenjem trudnoće. Trombocitopenija se također može pojaviti u sklopu preeklampsije, HELLP sindroma, trombotičke trombocitopenijske purpure, hemolitičko-uremičkog sindroma, a može biti i sekundarna pri sistemskom eritematoznom lupusu ili antifosfolipidnom sindromu. Kao oblik izolirane trombocitopenije javlja se imuna trombocitopenija. Neki trombocitopenični poremećaji ne utječu na ishod trudnoće, dok se drugi povezuju s visokim majčinskim i neonatalnim morbiditetom i mortalitetom. Zbog toga je bitno otkriti uzrok trombocitopenije u trudnoći kako bi se spriječile i na vrijeme počele liječiti moguće komplikacije i posljedice.

Abstract (english)

Thrombocytopenia affects 6-10 % of pregnancies and is the second most common hematologic disease in pregnancy. Thrombocytopenia occur when the number of platelets in the blood is less than 150 x 109/L. There are many potential causes of thrombocytopenia in pregnancy, some of which are specific to pregnancy, while others have an increased incidence during pregnancy. Thrombocytopenia in pregnancy can occur as an isolated disorder or as part of other disease. The most common form of isolated thrombocytopenia in pregnancy is gestational thrombocytopenia with a share of at least 75 %, with clinical symptoms that disappear after pregnancy, and laboratory findings normalized after termination of pregnancy. Thrombocytopenia can occur as part of pre-eclampsia, HELLP syndrome, thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, and may be secondary to the systemic lupus erythematosus and antiphospholipid syndrome. Immune thrombocytopenia occurs as a form of isolated thrombocytopenia. Some thrombocytopenic disorders do not affect the outcome of pregnancy, while others are associated with high maternal and neonatal morbidity and mortality. Therefore, it is important to detect pathological causes of thrombocytopenia in pregnancy so that possible complications and consequences can be predicted and managed.

• Keywords: trombocitopenija; trudnoća; uzroci; liječenje
• Keywords (english): thrombocytopenia; pregnancy; causes; management
• Language: croatian
• URN:NBN: urn:nbn:hr:105:364802
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-10-02 11:52:59