Količina i raspodjela abdominalne masti u osoba s morfološkim promjenama aorte kod MSCT aortografije

doctoral thesis

• Author: Maja Hrabak Paar; MBZ: 272131
• Mentor: Ranka Štern-Padovan (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2009-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Visceralna pretilost povezana je s razvojem metaboličkog sindroma i kardiovaskularnih bolesti. U našoj studiji istražili smo povezanost nastanka aneurizme abdominalne aorte i aterosklerotskih promjena aorte s količinom i raspodjelom abdominalnog masnog tkiva. Površina ukupnog, visceralnog i supkutanog abdominalnog masnog tkiva izmjerena je na CT presjeku u razini umbilikusa u 94 ispitanika s aneurizmom abdominalne aorte i 94 ispitanika kontrolne skupine te su izmjerene vrijednosti međusobno uspoređene. Pokazali smo da nastanak aneurizme abdominalne aorte nije povezan s količinom ukupnog i visceralnog masnog tkiva, dok supkutano masno tkivo ima „protektivni“ učinak na nastanak aneurizme. U kontrolnoj skupini određen je stupanj aterosklerotskih lezija segmenata aorte, te je utvrđeno da je količina visceralnog masnog tkiva pozitivno povezana s aterosklerotskim promjenama svih segmenata aorte, dok je učinak supkutanog masnog tkiva na razvoj aterosklerotskih promjena aorte zanemariv. Dobiveni rezultati upućuju na različitu etiopatogenezu aneurizmatskog proširenja aorte i stenozirajućih aterosklerotskih lezija.

Abstract (english)

Visceral adiposity is related to development of metabolic syndrome and cardiovascular diseases. We evaluated the relationship between the amount and distribution of abdominal adipose tissue with development of abdominal aortic aneurysm and atherosclerotic changes of the aorta. Total, visceral and subcutaneous abdominal fat areas were measured on a single axial CT scan at the level of umbilicus in 94 patients with abdominal aortic aneurysm and in 94 control subjects. We found no relationship between abdominal aortic aneurysm development and total and visceral fat areas, while subcutaneous adipose tissue had „protective“ effect on aneurysm development. In the control group, atherosclerotic plaques of aortic segments were graded, and positive relationship between visceral fat area and atherosclerotic lesions of all aortic segments was seen. The effect of subcutaneous fat tissue on development of aortic atherosclerosis was negligible. Our results indicate that aneurysmatic dilatation of the aorta and stenosing atherosclerotic lesions could be caused by different pathophysiological mechanisms.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:676183
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 86 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 08:54:07