Ovisnost ultrazvučnih parametara petne kosti u dječjoj dobi o genskim polimorfizmima

doctoral thesis

• Title (english): The association of ultrasonography indicators of the pediatric bone mineral density and genetic polymorpisms
• Author: Blaženka Miškić; MBZ: 175870
• Mentor: Darko Kaštelan (mentor)
• Committee member: nije dostupno (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2010-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences
• Universal decimal classification (UDC): 61 - Medical sciences

Abstract

Cilj ove disertacije bio je istražiti povezanost mineralne koštane gustoće kod djece s genetskim polimorfizmima. Disertacija je provedena na uzorku od 168 djece (85 djevojčica i 83 dječaka). Analizirani su učinci četiri gena na mineralnu koštanu gustoću: aromataze, IGF-1, receptora za estrogen i receptora za androgen. Osim ovoga, za svakog je ispitanika prikupljen i niz podataka iz ankete, koji su obuhvaćali prehrambene navike, kao i druge oblike ponašanja koji su povezani s koštanom gustoćom. Rezultati su ukazali na statistički značajnu povezanost mineralne koštane gustoće kod djece s genom za aromatazu CYP19, unosom kalcija i količinom tjelesne aktivnosti. Ovo potvrđuje složenu prirodu mineralne koštane gustoće i upućuje na mogućnost provedbe intervencijskog programa koji bi za cilj imao povećanje mineralne koštane gustoće kod djece, sve s ciljem smanjivanja šanse za nastanak osteoporoze i drugih štetnih posljedica smanjenja mineralne koštane gustoće.

Abstract (english)

The aim od this study was to investigate the association of the bone mineral density in children with genetic polymorphisms. The sample consisted of 168 chidlren (85 girls and 83 boys). Four polymorphisms were analysed – aromatase, IGF-1, estrogen receptor and androgen receptor. Furthermore, for each examinee a survey was used to estimate dietary habits and other possible behavioural patterns associated with bone mieral density. The results indicated significant association of CYP19 aromtase with bone mineral density, as well as significant association of BMD with calcium intake and physical activity. This confirms the complex nature of the bone mineral density determination and suggests the potential targets for intervention program which would be aimed at reducing the risks of developing osteoporosis and other adverse outcomes related to reduction of bone mineral density.

• Keywords: medicina
• Keywords (english): medicine
• Language: croatian
• URN:NBN: urn:nbn:hr:105:273397
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva (doktor/doktorica znanosti, područje biomedicine i zdravstva)
• Type of resource: Text
• Extent: 105 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-05-05 09:02:21