Povezanost ubrzanja prirasta tjelesne mase i druge faze retinopatije nedonoščadi

doctoral thesis

• Title (english): The association between the weight gain acceleration and the retinopathy of prematurity phase two
• Author: Ana Čolić
• Mentor: Nenad Vukojević (mentor)
• Committee member: Boris Filipović-Grčić (predsjednik povjerenstva)
• Committee member: Tomislav Jukić (član povjerenstva)
• Committee member: Snježana Kaštelan (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-07-03, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Prijevremeni porod odgađa normalnu vaskularizaciju retine koja se nastavlja abnormalnim rastom krvnog žilja u drugoj fazi retinopatije nedonoščadi. U nedonoščeta karakterističan je spori postnatalni prirast tjelesne mase sa slijedom nadoknade rasta.
Cilj ovog istraživanja bilo je dokazati da je ubrzanje prirasta tjelesne mase praćeno pojavom druge faze ROP-a.
Ispitivanu skupinu čini 52 nedonoščeta GD ≤ 28 tjedana i RM ≤ 1250 grama odabranih prema čimbenicima rizika za razvoj ROPa te isključnih utjecaja na prirast tjelesne mase. Retrospektivnom studijom utvrđeno je ubrzanje prirasta tjelesne mase te analizirana povezanost s pojavom druge faze ROP-a.
Medijan PMD početka ubrzanja prirasta tjelesne mase je 32 tjedna. Nije zabilježena pojava ROP-a prije ubrzanja a prva pojava ROP-a zabilježena je tjedan dana po početku ubrzanja prirasta tjelesne mase u 40.4 % ispitanika. U ukupno 44.3 % slučajeva ROP se pojavljuje u drugom i trećem tjednu po ubrzanju sa smanjenjem pojavnosti u slijedećim tjednima.
Dokazali smo povezanost ubrzanja prirasta tjelesne mase i druge proliferativne faze ROP-a čime smo pridonijeli saznanjima o patogenezi ove bolesti s mogućnošću primjene u kliničkoj praksi. Započinjanjem probira za ROP po utvrđivanju ubrzanja smanjio bi se broj izlaganja nedonoščadi proceduralnom stresu oftalmološkog pregleda.

Abstract (english)

Premature birth delays normal vascularization that continues with abnormal blood vessels growth in ROP phase two. In premature infants slow postnatal weight gain is followed by catch-up growth.
The aim of this research was to prove that weight gain acceleration is associated with emergence of ROP phase two.
52 premature infants GA ≤ 28 weeks and BW ≤ 1250 grams were selected according to risk factors for the ROP development and exclusive effects on weight gain. By retrospective study the acceleration of weight gain is determined and the association with occurrence of the second phase of ROP was analyzed.
The median PMA of the onset of weight gain acceleration is 32 weeks. No ROP was recorded before the acceleration, and ROP occured a week after the start of the acceleration in 40.4 % of subjects. Sum of occurrence for second and third week was 44.3 % with decrease of incidence in the following weeks.
We proved the connection between the weight gain acceleration and the second phase of ROP, contributing to the knowledge on ROP pathogenesis with possible clinical application. Initiating screening for ROP after acceleration might reduce exposures of premature infants to the procedural stress of the ophtalmic examination.

• Keywords: Retrospektivne studije; Učestalost; Dojenče; nedonošče; Debljanje
• Keywords (english): Retrospective Studies; Incidence; Infant; Premature; Weight Gain
• Language: croatian
• URN:NBN: urn:nbn:hr:105:002205
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 83 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-07-07 12:21:25