prikaz prve stranice dokumenta Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study
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Scientific paper - Original scientific paper
Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study
Pediatric Rheumatology, 20 (2022), 1; 96. https://doi.org/10.1186/s12969-022-00763-x
(Paediatric Rheumatology International Trials Organisation (PRINTO)) van Straalen, Joeri W.; de Roock, Sytze; Giancane, Gabriella; Consolaro, Alessandro; Rygg, Marite; Nordal, Ellen B.; Rubio-Pérez, Nadina; Jelušić, Marija; De Inocencio, Jaime; Vojinovic, Jelena; Wulffraat, Nico M.; Bruijning-Verhagen, Patricia C. J.; Ruperto, Nicolino; Swart, Joost F.

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van Straalen, J. W., de Roock, S., Giancane, G., Consolaro, A., Rygg, M., Nordal, E. B. ... Swart, J. F. (2022). Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study. Pediatric Rheumatology, 20. (1). doi: 10.1186/s12969-022-00763-x

van Straalen, Joeri W., et al. "Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study." Pediatric Rheumatology, vol. 20, no. 1, 2022. https://doi.org/10.1186/s12969-022-00763-x

van Straalen, Joeri W., Sytze de Roock, Gabriella Giancane, Alessandro Consolaro, Marite Rygg, Ellen B. Nordal, Nadina Rubio Pérez, et al. "Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study." Pediatric Rheumatology 20, no. 1 (2022). https://doi.org/10.1186/s12969-022-00763-x

van Straalen, J. W., et al. (2022) 'Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study', Pediatric Rheumatology, 20(1). doi: 10.1186/s12969-022-00763-x

van Straalen JW, de Roock S, Giancane G, Consolaro A, Rygg M, Nordal EB, and sur.. Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study. Pediatric Rheumatology [Internet]. 2022 November 14 [cited 2024 May 03];20(1). doi: 10.1186/s12969-022-00763-x

J. W. van Straalen, et al., "Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study", Pediatric Rheumatology, vol. 20, no. 1, November 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:509097. [Accessed: 03 May 2024]

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Metadata
Title (english)Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study
AuthorJoeri W. van Straalen
AuthorSytze de Roock
AuthorGabriella Giancane
AuthorAlessandro Consolaro
AuthorMarite Rygg
AuthorEllen B. Nordal
AuthorNadina Rubio-Pérez
AuthorMarija Jelušić
AuthorJaime De Inocencio
AuthorJelena Vojinovic
AuthorNico M. Wulffraat
AuthorPatricia C. J. Bruijning-Verhagen
AuthorNicolino Ruperto
AuthorJoost F. Swart
CollaborationPaediatric Rheumatology International Trials Organisation (PRINTO)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
Background: Etanercept (ETN) and adalimumab (ADA) are considered equally effective biologicals in the treatment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-reported well-being. The objective of this study was to determine whether ETN and ADA have a differential effect on patient-reported well-being in non-systemic JIA using real-world data. Methods: Biological-naive patients without a history of uveitis were selected from the international Pharmachild registry. Patients starting ETN were matched to patients starting ADA based on propensity score and outcomes were collected at time of therapy initiation and 3-12 months afterwards. Primary outcome at follow-up was the improvement in Juvenile Arthritis Multidimensional Assessment Report (JAMAR) visual analogue scale (VAS) well-being score from baseline. Secondary outcomes at follow-up were decrease in active joint count, adverse events and uveitis events. Outcomes were analyzed using linear and logistic mixed effects models. Results: Out of 158 eligible patients, 45 ETN starters and 45 ADA starters could be propensity score matched resulting in similar VAS well-being scores at baseline. At follow-up, the median improvement in VAS well-being was 2 (interquartile range (IQR): 0.0 - 4.0) and scores were significantly better (P = 0.01) for ETN starters (median 0.0, IQR: 0.0 - 1.0) compared to ADA starters (median 1.0, IQR: 0.0 - 3.5). The estimated mean difference in VAS well-being improvement from baseline for ETN versus ADA was 0.89 (95% CI: -0.01 - 1.78; P = 0.06). The estimated mean difference in active joint count decrease was -0.36 (95% CI: -1.02 - 0.30; P = 0.28) and odds ratio for adverse events was 0.48 (95% CI: 0.16 -1.44; P = 0.19). One uveitis event was observed in the ETN group. Conclusions: Both ETN and ADA improve well-being in non-systemic JIA. Our data might indicate a trend towards a slightly stronger effect for ETN, but larger studies are needed to confirm this given the lack of statistical significance.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePediatric Rheumatology
Numberingvol. 20, no. 1, 96
e-ISSN1546-0096
DOIhttps://doi.org/10.1186/s12969-022-00763-x
URN:NBNurn:nbn:hr:105:509097
Publication2022-11-14
Document URLhttps://ped-rheum.biomedcentral.com/articles/10.1186/s12969-022-00763-x
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-07-12 11:02:55