prikaz prve stranice dokumenta Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile
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Scientific paper - Original scientific paper
Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile
Pharmaceutics, 15 (2023), 6; 1660. https://doi.org/10.3390/pharmaceutics15061660
Perkušić, Mirna; Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Jakobušić Brala, Cvijeta; Pepić, Ivan; Lovrić, Jasmina; Safundžić Kučuk, Maša; Trenkel, Marie; Scherließ, Regina; Zadravec, Dijana; Kalogjera, Livije; Hafner, Anita

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Perkušić, M., Nižić Nodilo, L., Ugrina, I., Špoljarić, D., Jakobušić Brala, C., Pepić, I. ... Hafner, A. (2023). Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile. Pharmaceutics, 15. (6). doi: 10.3390/pharmaceutics15061660

Perkušić, Mirna, et al. "Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile." Pharmaceutics, vol. 15, no. 6, 2023. https://doi.org/10.3390/pharmaceutics15061660

Perkušić, Mirna, Laura Nižić Nodilo, Ivo Ugrina, Drago Špoljarić, Cvijeta Jakobušić Brala, Ivan Pepić, Jasmina Lovrić, et al. "Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile." Pharmaceutics 15, no. 6 (2023). https://doi.org/10.3390/pharmaceutics15061660

Perkušić, M., et al. (2023) 'Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile', Pharmaceutics, 15(6). doi: 10.3390/pharmaceutics15061660

Perkušić M, Nižić Nodilo L, Ugrina I, Špoljarić D, Jakobušić Brala C, Pepić I, and sur.. Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile. Pharmaceutics [Internet]. 2023 June 05 [cited 2024 May 08];15(6). doi: 10.3390/pharmaceutics15061660

M. Perkušić, et al., "Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile", Pharmaceutics, vol. 15, no. 6, June 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:502735. [Accessed: 08 May 2024]

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Title (english)Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile
AuthorMirna Perkušić
AuthorLaura Nižić Nodilo
AuthorIvo Ugrina
AuthorDrago Špoljarić
AuthorCvijeta Jakobušić Brala
AuthorIvan Pepić
AuthorJasmina Lovrić
AuthorMaša Safundžić Kučuk
AuthorMarie Trenkel
AuthorRegina Scherließ
AuthorDijana Zadravec
AuthorLivije Kalogjera
AuthorAnita Hafner
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Othorhinolaryngology and Head and Neck Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract (english)
Donepezil nasal delivery strategies are being continuously investigated for advancing therapy in Alzheimer’s disease. The aim of this study was to develop a chitosan-based, donepezil-loaded thermogelling formulation tailored to meet all the requirements for efficient nose-to-brain delivery. A statistical design of the experiments was implemented for the optimisation of the formulation and/or administration parameters, with regard to formulation viscosity, gelling and spray properties, as well as its targeted nasal deposition within the 3D-printed nasal cavity model. The optimised formulation was further characterised in terms of stability, in vitro release, in vitro biocompatibility and permeability (using Calu-3 cells), ex vivo mucoadhesion (using porcine nasal mucosa), and in vivo irritability (using slug mucosal irritation assay). The applied research design resulted in the development of a sprayable donepezil delivery platform characterised by instant gelation at 34 °C and olfactory deposition reaching a remarkably high 71.8% of the applied dose. The optimised formulation showed prolonged drug release (t1/2 about 90 min), mucoadhesive behaviour, and reversible permeation enhancement, with a 20-fold increase in adhesion and a 1.5-fold increase in the apparent permeability coefficient in relation to the corresponding donepezil solution. The slug mucosal irritation assay demonstrated an acceptable irritability profile, indicating its potential for safe nasal delivery. It can be concluded that the developed thermogelling formulation showed great promise as an efficient donepezil brain-targeted delivery system. Furthermore, the formulation is worth investigating in vivo for final feasibility confirmation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePharmaceutics
Numberingvol. 15, no. 6, 1660
e-ISSN1999-4923
DOIhttps://doi.org/10.3390/pharmaceutics15061660
URN:NBNurn:nbn:hr:105:502735
Publication2023-06-05
ProjectNumber: UIP-2017-05-4592
Title (croatian): Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini
Acronym: OptiNasalSpray
Leader: Anita Hafner
Jurisdiction: Croatia
Funding stream: UIP
Document URLhttps://www.mdpi.com/1999-4923/15/6/1660
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-09-18 08:39:39