Predikcija uspješnosti liječenja Crohnove bolesti temeljem "Pedijatrijskog indeksa aktivnosti Crohnove bolesti" u fenotipski različitim prezentacijama bolesti

master's thesis

• Title (english): Crohn's disease and Pediatric Crohn's Disease Activity Index, treatment outcomes in different phenotype presentations
• Author: Ivana Bilić
• Mentor: Jurica Vuković (mentor)
• Committee member: Irena Senečić-Čala (predsjednik povjerenstva)
• Committee member: Marija Jelušić (član povjerenstva)
• Committee member: Jurica Vuković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

UVOD
Pedijatrijski indeks aktivnosti Crohnove bolesti PCDAI jedna je od neinvazivnih metoda praćenja učinka liječenja Crohnove bolesti ( u pedijatrijskoj populaciji.

CILJ
Cilj je ovog diplomskog rada usporediti vrijednost PCDAI ja, fenotip i težinu bolesti u muških i ženskih bolesnika, utvrditi postoje li razlike u kliničkoj slici između bolesnika s ranijim i kasnijim početkom bolesti, te ispitati koliko dobro vrijednost PC DAI ja odražava upalnu aktivnost sluznice crijeva.

METODE
U ovo retrospektivno kohortno istraživanje uključeni su bolesnici s Crohnovom bolesti koji su se liječili u Kliničkom bolničkom centru Zagreb u Zavodu za gastroenterologiju, hepatologiju i prehranu u razdoblju od 1. siječnja 2011. do 1.siječnja 2023. godine. Podaci su prikupljeni na osnovi elektroničkih podataka BIS a (Bolničkog informacijskog sustava).

REZULTATI
Od ukupno analizirana 44 bolesnika, 30 ( je bilo muškog, a 14 ( ženskog spola. Većina bolesnika se u trenutku postavljanja dijagnoze prezentirala upalnim fenotipom (37 84.1%) i blagim oblikom bolesti (31 bolesnik 70.5%). Usporedbom bolesnika po spolu nije bilo značajne razlike u dobi pojave prvog simptoma, učestalosti izuzetno ranog i kasnijeg početka bolesti, kao niti u učestalosti različitih fenotipova CB a. Kod bolesnika s ranim, ali i u onih s kasnijim početkom bolesti najčešći fenotip CB a je bio upalni. PCDAI se nije razlikovao u ove dvije skupine ispitanika (p= Između bolesnika s blagim i onih s težim oblikom bolesti rema vrijednosti PCDAI a nije utvrđena fenotipska raznorodnost (p= najčešći oblik u obe skupine je bio upalni.

ZAKLJUČAK
Spol i dob kad je bolest počela ne utječu na fenotip i težinu Crohnove bolesti. Vrijednost PCDAI a se ne podudara najbolje sa upalnim stanjem sluznice crijeva te zbog toga nije pouzdan alat za praćenje uspjeha liječenja CB a.

Abstract (english)

INTRODUCTION
The Pediatric Crohn Disease Activity Index (P CDAI is one of a non invasive method s for monitoring the effect of Crohn's disease treatment in the pediatric population.

AIM
The aim of this paper is to compare the value of PCDAI, the phenotype and severity of the disease between male and female patients, to determine whether there are differences in the clinical picture between patients with earlier and later onset of the disease, and to examine how well the value of PCDAI reflects the inflammatory activity of the intestinal mucosa.

METHODS
This retrospective cohort study included patients with Crohn's disease who were treated at the Zagreb Clinical Hospital Center in the Department of Gastroenterology, Hepatology and Nutrition in the period from January 1, 2011 to January 1, 2023. BIS (Hospital Information System) was reviewed as source of dana.

RESULTS
44 patients were analyzed, of which 30 ( were male and 14 ( were female. At the time of diagnosis, the majority of patients presented with an inflammatory phenotype (37 patients 84.1% and a mild form of the disease (31 patients 70.5%). By comparing patients by gender, no statistically s ignificant difference was found according the age of onset of the first symptom, the frequency of early and later onset of the disease, nor the frequency of different CB phenotypes. In patients with early and also in those with a later onset of the disease the most common phenotype of CB was inflammatory, and no statistically significant difference was found in the PCDAI value between these two groups of subjects (p= According to the PCDAI value, no statistically significant difference in phenotype was found between patients with a mild and those with a more severe form of the disease (p= the most common form in both groups was inflammatory.

CONCLUSION
Gender and time of disease onset do not influence the phenotype and severity of Crohn's disease. The value of PCDAI does not correspond well with the inflammatory state of the intestinal mucosa and therefore is not a reliable tool for monitoring the outcome of CB treatment.

• Keywords: PCDAI; Crohnova bolest; fenotip
• Keywords (english): PCDAI; Crohn's disease; phenotype
• Language: croatian
• URN:NBN: urn:nbn:hr:105:324150
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-23 09:35:00