Radiološke karakteristike papilarnih lezija u dojci

master's thesis

• Title (english): Radiological characteristic of papillary lesions in breast
• Author: Lucija Lučev
• Mentor: Maja Prutki (mentor)
• Committee member: Maja Hrabak Paar (predsjednik povjerenstva)
• Committee member: Gordana Ivanac (član povjerenstva)
• Committee member: Maja Prutki (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Radiology); Zagreb
• Defense date and country: 2023-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology

Abstract

Papilarne lezije dojke prema klasifikaciji tumora dojke koju je 2019. godine izdala Svjetska zdravstvena organizacija dijele se na intraduktalne papilome, intraduktalne papilarne karcinome, inkapsulirane papilarne karcinome, invazivne inkapsulirane papilarne karcinome, solidne papilarne karcinome in situ, invazivne solidne papilarne karcinome i intraduktalne papilarne adenokarcinome. Rijetki su to tumori koji predstavljaju izazov za sve liječnike uključene u postavljanje dijagnoze.

Oni su biološki, klinički, radiološki i histološki heterogena skupina tumora koja obuhvaća benigne, lezije nesigurnog malignog potencijala i maligne lezije. Također, razlikujemo neinvazivne i invazivne tumore među malignim lezijama.

Glavne slikovne pretrage za dijagnostiku bolesti dojke su mamografija, ultrazvuk i magnetska rezonancija te to vrijedi i za papilarne tumore. Klinički i radiološki sumnjive lezije dojke uzorkuju se biopsijom širokom iglom ili vakuumom asistiranom biopsijom te se konačna dijagnoza postavlja na osnovi patohistološkog nalaza uz dokazivanje određenih citomorfoloških i imunofenotipskih karakteristika.

Glavna zajednička histološka karakteristika svih papilarnih tumora je prisutnost papila najčešće s arborizirajućom fibrovaskularnom stromom, što nije svojstveno zdravom tkivu dojke.

Problem predstavlja činjenica da tumori ponekad imaju preklapajuće morfološke i imunofenotipske značajke što otežava patolozima postavljanje dijagnoze te se javlja problem njihovog i pretjeranog i nedovoljnog dijagnosticiranja.

U ovom radu raspravlja se o kliničkim, radiološkim i patohistološkim posebnostima svakog od tumora ove skupine te o preporukama za njihovo liječenje.

Abstract (english)

According to the 2019 World Health Organization classification of tumors of the breast, papillary breast lesions are divided into intraductal papillomas, intraductal papillary carcinomas, encapsulated papillary carcinomas, encapsulated papillary carcinomas with invasion, solid papillary carcinomas in situ, solid papillary carcinomas with invasion and intraductal papillary adenocarcinoma with invasion. They are rare tumors that pose a challenge for all doctors involved in making a diagnosis.

They are a biologically, clinically, radiologically and histologically heterogeneous group of tumors that includes both benign, precursor, and malignant lesions. It is also important to distinguish between non-invasive and invasive tumors among malignant lesions.

The main imaging methods for diagnosing breast diseases are mammography, ultrasound and magnetic resonance imaging. Radiologically suspicious breast lesions are sampled with a core-needle biopsy or a vacuum-assisted biopsy and the final diagnosis is made based on the pathohistological findings and the presence of certain cytomorphological and immunophenotypic characteristics.

The main common histological characteristic of all papillary tumors is the presence of a papilla, usually with an arborizing fibrovascular tree, which is not the characteristic of a healthy breast tissue.

The problem lies in the fact that papillary lesions sometimes have overlapping morphological and immunophenotypic properties, which makes it difficult for pathologists to establish a diagnosis and then we are faced with a problem of both overdiagnosing and underdiagnosing those tumors.

In this thesis, the clinical, radiological and pathohistological characteristics of each tumor from this group is discussed, as well as recommendations for their treatment.

• Keywords: papilarne lezije; rak dojke; biopsija dojke
• Keywords (english): papillary lesions; breast cancer; breast biopsy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:964949
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-10-26 09:22:44