Nasljedni poremećaji funkcije trombocita u djece

master's thesis

• Title (english): Hereditary disorders of platelet function in children
• Author: Antonela Čirko
• Mentor: Ernest Bilić (mentor)
• Committee member: Ljubica Rajić (predsjednik povjerenstva)
• Committee member: Marija Jelušić (član povjerenstva)
• Committee member: Ernest Bilić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

Kvalitativni poremećaji funkcije i stvaranja trombocita čine veliku skupinu pojedinačno rijetkih bolesti koje pokrivaju mnoštvo genetskih defekata slične kliničke slike najčešće u obliku mukokutanih krvarenja. Nasljedne trombocitopatije mogu imati cijeli spektar različitih manifestacija od petehija i modrica do spontanih krvarenja. Zbog najčešće blagih simptoma često ostaju neotkrivene. Nešto se češće dijagnosticiraju u žena u vrijeme puberteta zbog produljenih menstruacija. Cilj rada bilo je ustanoviti intenzitet i učestalost krvarenja kod djece s poremećenom funkcijom trombocita, a obuhvaćena su djeca u dobi od rođenja do navršenih 18 godina života kojima je dokazan poremećaj funkcije trombocita, a koja su obrađivana u Zavodu za hematologiju Klinike za pedijatriju Kliničkog bolničkog centra Zagreb u vremenskom razdoblju od 1. siječnja 1999. godine do 31. prosinca 2013. godine. Rezultati su pokazali dvostruko veću učestalost u djevojčica među kojima je najčešće izraženi simptom bila obilna mjesečnica.

Abstract (english)

Qualitative disorders of platelet function constitute a large group of individually rare diseases that cover a multitude of genetic defects with similar clinical picture as frequent mucocutaneous bleeding. Hereditary thrombasthenias are a relatively rare cause of hemorrhagic diathesis, but can have a whole range of different manifestations of petechiae and bruises to spontaneous bleeding. Because usually mild symptoms often remain undetected. Among women in the fertile period they are a common cause of unexplained menorrhagia. The aim of the study was to determine the intensity and frequency of bleeding in children with impaired platelet function aged from birth to the age of 18 that came in the Division of Hematology, Department of Pediatrics, University Hospital Center Zagreb in the period from 1th January 1999 to 31th December 2013. Results showed twice the incidence in girls, among them the most common symptom was profused menstruation.

• Keywords: trombocitopatije; djeca
• Keywords (english): thrombasthenias; children
• Language: croatian
• URN:NBN: urn:nbn:hr:105:913237
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-10-05 09:50:01