| Abstract | Cilj ovog istraživanja bio je analizirati učestalost venskih tromboembolija (VTE) i arterijskih tromboza (AT) u hospitaliziranih COVID-19 bolesnika i potencijalne razlike tijekom pojedinih valova COVID-19.
Retrospektivno smo analizirali podatke registra hospitaliziranih COVID-19 bolesnika liječenih u Kliničkoj bolnici Dubrava od 3/2020 do 6/2022. VTE i AT morale su biti dokazane objektivnim radiološkim i laboratorijskim metodama i zabilježene u medicinskoj dokumentaciji. Kao VTE bilježene su duboka venska tromboza (DVT) i plućna embolija (PE). Kao AT bilježene su infarkt miokarda (MI), cerebrovaskularni infarkt (CVI), periferne arterijske tromboze (per AT) i mezenterijalne arterijske tromboze (mez AT). Valovi bolesti definirani su prema dominantnom soju virusa: prvi (alfa), drugi (beta/gama), treći (delta) i četvrti (omikron).
Analizirano je ukupno 7190 uzastopno hospitaliziranih COVID-19 bolesnika. Učestalost VTE statistički se značajno razlikovala između valova bolesti, kako ukupno (5.3%, 7.7%, 3.5%, 3.5%; P<0.001) tako i za DVT (2.1%, 2.6%, 0.8%, 1.5%; P=0.020) i PE (3.6%, 6%, 3.1%, 3%; P<0.001).
Učestalost AT nije se statistički značajno razlikovala između pojedinih valova bolesti za ukupni broj događaja (5.7%, 5.2%, 4%, 4.3%; P=0.198), kao ni za MI (1.7%, 1.8%, 1.6%, 1.9%; P=0.942), per AT (1.1%, 1.2%, 1.6%, 1.1%; P=0.729) i mez AT (0.3%, 0.4%, 0%, 0.2%; P=0.322). Učestalost CVI se statistički značajno razlikovala između valova bolesti (2.7%, 1.7%, 1.6%, 1.1%; P=0.014).
Najviše stope VTE detektirane su tijekom beta/gama, a najniže tijekom delta sojem dominiranog vala bolesti. Stope AT nisu se razlikovale tijekom valova bolesti s izuzetkom CVI gdje su zabilježene kontinuirano silazne stope od alfa do omikron sojem dominiranih valova bolesti. |
| Abstract (english) | The aim of this study was to analyze the frequency of venous thromboembolism (VTE) and arterial thrombosis (AT) in hospitalized COVID-19 patients and potential differences during different waves of COVID-19.
We retrospectively analyzed data from the registry of hospitalized COVID-19 patients treated at Dubrava Clinical Hospital from 3/2020 to 6/2022. VTE and AT had to be confirmed by objective radiological and laboratory methods and recorded in medical documentation. Deep vein thrombosis (DVT) and pulmonary embolism (PE) were recorded as VTE. Myocardial infarction (MI), cerebrovascular infarction (CVI), peripheral arterial thrombosis (per AT), and mesenteric arterial thrombosis (mes AT) were recorded as AT. Disease waves were defined according to the dominant virus strain: first (alpha), second (beta/gamma), third (delta), and fourth (omicron).
A total of 7,190 consecutive hospitalized COVID-19 patients were analyzed. The frequency of VTE significantly differed between disease waves, both overall (5.3%, 7.7%, 3.5%, 3.5%; P<0.001) and for DVT (2.1%, 2.6%, 0.8%, 1.5%; P=0.020) and PE (3.6%, 6%, 3.1%, 3%; P<0.001).
The frequency of AT did not significantly differ between individual disease waves for the total number of events (5.7%, 5.2%, 4%, 4.3%; P=0.198), nor for MI (1.7%, 1.8%, 1.6%, 1.9%; P=0.942), per AT (1.1%, 1.2%, 1.6%, 1.1%; P=0.729), and mes AT (0.3%, 0.4%, 0%, 0.2%; P=0.322). The frequency of CVI significantly differed between disease waves (2.7%, 1.7%, 1.6%, 1.1%; P=0.014).
The highest rates of VTE were detected during the beta/gamma wave, while the lowest rates were observed during the delta variant-dominated wave. AT rates did not differ during the disease waves, except for CVI, which showed continuously decreasing rates from the alpha to the omicron variant-dominated waves. |
