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Scientific paper - Review paper
The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?
Antioxidants, 12 (2023), 4; 856. https://doi.org/10.3390/antiox12040856
Milković, Lidija; Žarković, Neven; Marušić, Zlatko; Žarković, Kamelija; Jaganjac, Morana

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Milković, L., Žarković, N., Marušić, Z., Žarković, K. & Jaganjac, M. (2023). The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?. Antioxidants, 12. (4). doi: 10.3390/antiox12040856

Milković, Lidija, et al. "The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?." Antioxidants, vol. 12, no. 4, 2023. https://doi.org/10.3390/antiox12040856

Milković, Lidija, Neven Žarković, Zlatko Marušić, Kamelija Žarković and Morana Jaganjac. "The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?." Antioxidants 12, no. 4 (2023). https://doi.org/10.3390/antiox12040856

Milković, L., et al. (2023) 'The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?', Antioxidants, 12(4). doi: 10.3390/antiox12040856

Milković L, Žarković N, Marušić Z, Žarković K, Jaganjac M. The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?. Antioxidants [Internet]. 2023 April 01 [cited 2024 December 31];12(4). doi: 10.3390/antiox12040856

L. Milković, N. Žarković, Z. Marušić, K. Žarković and M. Jaganjac, "The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?", Antioxidants, vol. 12, no. 4, April 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:613184. [Accessed: 31 December 2024]

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Metadata
Title (english)The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?
AuthorLidija Milković
AuthorNeven Žarković
AuthorZlatko Marušić
AuthorKamelija Žarković
AuthorMorana Jaganjac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
It is well known that oxidative stress and lipid peroxidation (LPO) play a role in physiology and pathology. The most studied LPO product with pleiotropic capabilities is 4-hydroxynonenal (4-HNE). It is considered as an important mediator of cellular signaling processes and a second messenger of reactive oxygen species. The effects of 4-HNE are mainly attributed to its adduction with proteins. Whereas the Michael adducts thus formed are preferred in an order of potency of cysteine > histidine > lysine over Schiff base formation, it is not known which proteins are the preferred targets for 4-HNE under what physiological or pathological conditions. In this review, we briefly discuss the methods used to identify 4-HNE–protein adducts, the progress of mass spectrometry in deciphering the specific protein targets, and their biological relevance, focusing on the role of 4-HNE protein adducts in the adaptive response through modulation of the NRF2/KEAP1 pathway and ferroptosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAntioxidants
Numberingvol. 12, no. 4, 856
e-ISSN2076-3921
DOIhttps://doi.org/10.3390/antiox12040856
URN:NBNurn:nbn:hr:105:613184
Publication2023-04-01
Document URLhttps://www.mdpi.com/2076-3921/12/4/856
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-11-21 08:24:31