prikaz prve stranice dokumenta Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements
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Scientific paper - Review paper
Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements
World Journal of Critical Care Medicine, 12 (2023), 2; 71-88. https://doi.org/10.5492/wjccm.v12.i2.71
Mehta, Yatin; Paul, Rajib; Ansari, Abdul Samad; Banerjee, Tanmay; Gunaydin, Serdar; Nassiri, Amir Ahmad; Pappalardo, Federico; Premužić, Vedran; Sathe, Prachee; Singh, Vinod; Vela, Emilio Rey

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Mehta, Y., Paul, R., Ansari, A. S., Banerjee, T., Gunaydin, S., Nassiri, A. A. ... Vela, E. R. (2023). Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements. World Journal of Critical Care Medicine, 12. (2), 71-88. doi: 10.5492/wjccm.v12.i2.71

Mehta, Yatin, et al. "Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements." World Journal of Critical Care Medicine, vol. 12, no. 2, 2023, pp. 71-88. https://doi.org/10.5492/wjccm.v12.i2.71

Mehta, Yatin, Rajib Paul, Abdul Samad Ansari, Tanmay Banerjee, Serdar Gunaydin, Amir Ahmad Nassiri, Federico Pappalardo, et al. "Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements." World Journal of Critical Care Medicine 12, no. 2 (2023): 71-88. https://doi.org/10.5492/wjccm.v12.i2.71

Mehta, Y., et al. (2023) 'Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements', World Journal of Critical Care Medicine, 12(2), pp. 71-88. doi: 10.5492/wjccm.v12.i2.71

Mehta Y, Paul R, Ansari AS, Banerjee T, Gunaydin S, Nassiri AA, and sur.. Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements. World Journal of Critical Care Medicine [Internet]. 2023 [cited 2025 March 28];12(2):71-88. doi: 10.5492/wjccm.v12.i2.71

Y. Mehta, et al., "Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements", World Journal of Critical Care Medicine, vol. 12, no. 2, pp. 71-88, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:271509. [Accessed: 28 March 2025]

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Metadata
Title (english)Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements
AuthorYatin Mehta
AuthorRajib Paul
AuthorAbdul Samad Ansari
AuthorTanmay Banerjee
AuthorSerdar Gunaydin
AuthorAmir Ahmad Nassiri
AuthorFederico Pappalardo
AuthorVedran Premužić
AuthorPrachee Sathe
AuthorVinod Singh
AuthorEmilio Rey Vela
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Despite various therapies to treat sepsis, it is one of the leading causes of mortality in the intensive care unit patients globally. Knowledge about the pathophysiology of sepsis has sparked interest in extracorporeal therapies (ECT) which are intended to balance the dysregulation of the immune system by removing excessive levels of inflammatory mediators. Aim: To review recent data on the use of ECT in sepsis and to assess their effects on various inflammatory and clinical outcomes. Methods: In this review, an extensive English literature search was conducted from the last two decades to identify the use of ECT in sepsis. A total of 68 articles from peer-reviewed and indexed journals were selected excluding publications with only abstracts. Results: Results showed that ECT techniques such as high-volume hemofiltration, coupled plasma adsorption/filtration, resin or polymer adsorbers, and CytoSorb® are emerging as adjunct therapies to improve hemodynamic stability in sepsis. CytoSorb® has the most published data in regard to the use in the field of septic shock with reports on improved survival rates and lowered sequential organ failure assessment scores, lactate levels, total leucocyte count, platelet count, interleukin- IL-6, IL-10, and TNF levels. Conclusion: Clinical acceptance of ECT in sepsis and septic shock is currently still limited due to a lack of large random clinical trials. In addition to patient-tailored therapies, future research developments with therapies targeting the cellular level of the immune response are expected.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Critical Care Medicine
Numberingvol. 12, no. 2, pp. 71-88
p-ISSN2220-3141
DOIhttps://doi.org/10.5492/wjccm.v12.i2.71
URN:NBNurn:nbn:hr:105:271509
Publication2023
Document URLhttps://www.wjgnet.com/2220-3141/full/v12/i2/71.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-11-24 14:35:20