The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression

Scientific paper - Original scientific paper

• Author: Matea Nikolac Perković
• Author: Martin Gredičak
• Author: Marina Šagud
• Author: Gordana Nedić Erjavec
• Author: Suzana Uzun
• Author: Nela Pivac
• Author's institution: University of Zagreb; School of Medicine; (Department of Psychiatry and Psychological Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry

Abstract (english)

Introduction: Recent evidence from the studies evaluating the association between brain-derived neurotrophic factor (BDNF) concentration/levels, BDNF Val66Met (rs6265) polymorphism, and major depressive disorders, referred as depression, and the association between BDNF levels and/or BDNF Val66Met with the treatment response in depression is presented.

Areas covered: This mini review focuses on the changes in the peripheral BDNF levels in blood (serum, plasma, platelets) in patients with depression before or after treatment with antidepressant drugs or different therapeutic strategies. In addition, this review describes the recent data on the possible association between different antidepressants/therapeutic strategies and the particular BDNF Val66Met genotypes, evaluating the risk alleles associated with the response in patients with depression.

Expert opinion: BDNF has an important role in the pathophysiology and treatment response in depression. Most data reveal that peripheral BDNF levels are lower before than after antidepressant treatment and might be used as potential biomarkers of therapeutic response. Novel therapeutic strategies should target restoring/increasing BDNF levels.

• Keywords (english): Antidepressive Agents / therapeutic use; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / therapeutic use; Depression / diagnosis; Depression / drug therapy; Depression / etiology; Depressive Disorder, Major / diagnosis; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / genetics; Genotype; Humans; Polymorphism, Single Nucleotide
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Expert Review of Molecular Diagnostics
• Numbering: vol. 23, no. 4, pp. 283-296
• p-ISSN: 1473-7159
• e-ISSN: 1744-8352
• DOI: https://doi.org/10.1080/14737159.2023.2200937
• URN:NBN: urn:nbn:hr:105:267765
• Publication: 2023-04-14
• Document URL: https://www.tandfonline.com/doi/full/10.1080/14737159.2023.2200937
• Type of resource: Text
• Access conditions: Open access; Embargo expiration date: 2024-05-01
• Created on: 2024-01-08 08:42:18