Ekvivalent: Non-Hodgkinov limfom frontalnog sinusa – prikaz slučaja i pregled literature

professional thesis

• Title (english): Equivalent: Non-Hodkin's lymphoma of the frontal sinus. Case report and literature review
• Author: Sandra Doko
• Mentor: Marko Velimir Grgić (mentor)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2023-09-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Primary frontal sinus Non-Hodgkin's lymphoma (NHL) is an extremely rare condition with 20 cases published in the existing literature to date. We describe a 64-year-old patient who presented with right orbital pain, severe headache and diplopia. He was initially diagnosed with acute exacerbation of chronic rhinosinusitis and responded well to antibiotic treatment, but his symptoms returned. The diagnosis of frontal sinus NHL was made only after functional endoscopic frontal sinus surgery was performed in general anaesthesia. A tumor mass, which was filling the entire right frontal sinus, was completely removed and sent to histopathological examination. The patient was finally diagnosed with diffuse large B-cell lymphoma of the frontal sinus and referred to the haematology department for tumor staging and chemotherapy. This case emphasizes the importance of early clinical suspicion and diagnosis, which leads to early treatment and better prognosis.

Abstract (croatian)

Primarni Non-Hodgkinov limfom (NHL) frontalnog sinusa izrazito je rijedak, s do sada opisanih 20 slučajeva u literaturi. Prikazujemo 64-godišnjeg bolesnika koji se prezentirao simptomima desnostrane orbitalne boli i jake glavobolje s dvoslikama. Najprije je postavljena dijagnoza akutne egzacerbacije kroničnog rinosinuitisa uz dobar odgovor na započetu antibiotsku terapiju, ali i povratak simptoma nakon prekida liječenja. Definitivna dijagnoza Non-Hodgkinovog limfoma frontalnog sinusa postavljena je tek nakon učinjene funkcionalne endoskopske operacije sinusa u općoj anesteziji. Tumorsko tkivo koje je ispunjavalo cijelu desnu polovicu frontalnog sinusa odstranjeno je u cijelosti i poslano na patohistološku analizu. Bolesniku je dijagnosticiran difuzni B-velikostanični limfom frontalnog sinusa nakon čega je upućen na odjel hematologije radi daljnje dijagnostike i liječenja kemoterapijom. Želimo naglasiti važnost rane kliničke sumnje i rane dijagnoze ove bolesti, što doprinosi ranijem početku liječenja i boljoj prognozi.

• Keywords: frontal sinus; paranasal sinus; diffuse large B-cell lymphoma; non-Hodgkin's lymphoma
• Keywords (croatian): frontalni sinus; paranazalni sinus; difuzni B velikostanični limfom; non Hodgkinov limfom
• Language: english
• URN:NBN: urn:nbn:hr:105:107723
• Study programme: Title: Otorhinolaryngology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra otorinolaringologije (sveučilišni/a magistar/magistra otorinolaringologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-02-05 12:04:24