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Scientific paper - Review paper
From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities
Pharmaceuticals, 16 (2023), 12; 1699. https://doi.org/10.3390/ph16121699
Sikirić, Predrag; Boban Blagaić, Alenka; Krezic, Ivan; Žižek, Helena; Kalogjera, Luka; Smoday, Ivan Maria; Vuković, Vlasta; Oroz, Katarina; Chiddenton, Helen Marie; Buric, Sara; Antunović, Marko; Gojković, Slaven; Štrbe, Sanja; Skočić, Milena; Sikirić, Sunčana; Milavić, Marija; Beketić Orešković, Lidija; Kokot, Antonio; Koprivanac, Antun; Dobrić, Ivan; Sever, Marko; Starešinić, Mario; Batelja Vuletić, Lovorka; Škrtić, Anita; Seiwerth, Sven More authors...

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Sikirić, P., Boban Blagaić, A., Krezic, I., Žižek, H., Kalogjera, L., Smoday, I. M. ... Seiwerth, S. (2023). From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities. Pharmaceuticals, 16. (12). doi: 10.3390/ph16121699

Sikirić, Predrag, et al. "From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities." Pharmaceuticals, vol. 16, no. 12, 2023. https://doi.org/10.3390/ph16121699

Sikirić, Predrag, Alenka Boban Blagaić, Ivan Krezic, Helena Žižek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vuković, et al. "From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities." Pharmaceuticals 16, no. 12 (2023). https://doi.org/10.3390/ph16121699

Sikirić, P., et al. (2023) 'From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities', Pharmaceuticals, 16(12). doi: 10.3390/ph16121699

Sikirić P, Boban Blagaić A, Krezic I, Žižek H, Kalogjera L, Smoday IM, and sur.. From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities. Pharmaceuticals [Internet]. 2023 December 07 [cited 2024 December 19];16(12). doi: 10.3390/ph16121699

P. Sikirić, et al., "From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities", Pharmaceuticals, vol. 16, no. 12, December 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:485424. [Accessed: 19 December 2024]

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Title (english)From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities
AuthorPredrag Sikirić
AuthorAlenka Boban Blagaić
AuthorIvan Krezic
AuthorHelena Žižek
AuthorLuka Kalogjera
AuthorIvan Maria Smoday
AuthorVlasta Vuković
AuthorKatarina Oroz
AuthorHelen Marie Chiddenton
AuthorSara Buric
AuthorMarko Antunović
AuthorSlaven Gojković
AuthorSanja Štrbe
MBZ: 319335
AuthorMilena Skočić
AuthorSunčana Sikirić
AuthorMarija Milavić
AuthorLidija Beketić Orešković
AuthorAntonio Kokot
AuthorAntun Koprivanac
AuthorIvan Dobrić
AuthorMarko Sever
AuthorMario Starešinić
AuthorLovorka Batelja Vuletić
AuthorAnita Škrtić
AuthorSven Seiwerth
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Physiology and Immunology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients. Szabo’s cysteamine duodenal ulcer as the dopamine duodenal healing and cysteamine as a dopamine antagonist signifies the dopamine agonists anti-ulcer effect and dopamine antagonists ulcerogenic effect. From these viewpoints, we focused on dopamine and gastric ulcer healing. We mentioned antecedent studies on the dopamine presence in the stomach and gastric juice. Then we reviewed, in the timeline, therapy significance arising from the anti-ulcer potency of the various dopamine agonists, which is highly prevailing over the quite persistent beneficial evidence arising from the various dopamine antagonists. Meanwhile, the beneficial effects of several peptides (i.e., amylin, cholecystokinin, leptin, and stable gastric pentadecapeptide BPC 157, suggested as an acting mediator of the dopamine brain-gut axis) were included in the dopamine gastric ulcer story. We attempt to resolve dopamine agonists/antagonists issue with the dopamine significance in the stress (cysteamine as a prototype of the duodenal stress ulcer), and cytoprotection (cysteamine in small dose as a prototype of the cytoprotective agents; cysteamine duodenal ulcer in gastrectomized rats). Thereby, along with dopamine agonists’ beneficial effects, in special circumstances, dopamine antagonists having their own ulcerogenic effect may act as “mild stress (or)” or “small irritant” counteracting subsequent strong alcohol or stress procedure-induced severe lesions in this particular tissue. Finally, in the conclusion, as a new improvement in further therapy, we emphasized the advantages of the dopamine agents’ application in lower gastrointestinal tract therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePharmaceuticals
Numberingvol. 16, no. 12, 1699
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph16121699
URN:NBNurn:nbn:hr:105:485424
Publication2023-12-07
Document URLhttps://www.mdpi.com/1424-8247/16/12/1699
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-03-01 11:19:19