| Abstract (english) | Because of their widespread use, fragrances are among the most common causes of contact allergic dermatitis, second only to nickel. During a five-year period 3,065 patients with contact dermatitis were patch tested using a specific mix of fragrances. 509 (16.6%) patients were allergic to the fragrance mix, while 258 (8.4%) patients exhibited an allergic reaction to Myroxylon pereirae (balsam of Peru). Between those 509 patients, 157 were patch tested with eight individual substances contained in the fragrance mix: cinnamal, cinnamyl alcohol, eugenol, isoeugenol, geraniol, hydroxycitronellal, alpha-amyl cinnamal and Evernia prunastri (oak moss). The most frequent allergens were isoeugenol 57.9% (91/157), eugenol 55.4% (87/157), cinnamyl alcohol 34.4% (54/157) and Evernia prunastri (oak moss) 24.2% (38/157). There were 62 patients (39.5%) who exhibited an allergic reaction to both the fragrance mix and Myroxylon pereirae (balsam of Peru). The results prove the importance of avoiding allergens in daily life, especially in industrial and cosmetic products. In order to prevent ACD, better cooperation between industry and dermatologists is needed. |
| Abstract (croatian) | Uz nikal, mirisi su zbog svoje široke uporabe najčešći uzrok alergijskog kontaktnog dermatitisa. Tijekom perioda od
pet godina 3065 pacijenata s kontaktnim dermatitisom bilo je podvrgnuto testiranju na mješavinu mirisa. 509 (16,6%)
pacijenata bilo je alergično na mješavinu mirisa, a 258 (8,4%) na peruvijanski balzam. Među njima, 157 pacijenata je
testirano na pojedine komponente mirisa koje uključuju: cimetni aldehid, cimetni alkohol, eugenol, izoeugenol, geraniol,
hidroksicitronelal, alfa-amil cimetni aldehid te ekstrakt hrastove mahovine. Najčešći alergeni bili su izoeugenol
57,9% (91/157), eugenol 55,4% (87/157), cimetni alkohol 34,4% (54/157) te ekstrakt hrastove mahovine 24,2% (38/157).
62 pacijenata (39,5%) imalo je pozitivnu reakciju na oba alergena – mješavinu mirisa i peruvijanski balzam. Rezultati
upućuju na važnost izbjegavanja alergena u dnevnom životu, industriji i kozmetičkim pripravcima. Potrebna je bolja
komunikacija između farmaceuta, dermatovenerologa i industrije zbog prevencije alergijskog kontaktnog dermatitisa. |
