prikaz prve stranice dokumenta Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy
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Scientific paper - Original scientific paper
Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy
PLoS One, 7 (2012), 1; e29803. https://doi.org/10.1371/journal.pone.0029803
Filipović, Boris; Matak, Ivica; Bach-Rojecky, Lidija; Lacković, Zdravko

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Filipović, B., Matak, I., Bach Rojecky, L. & Lacković, Z. (2012). Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy. PLoS One, 7. (1). doi: 10.1371/journal.pone.0029803

Filipović, Boris, et al. "Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy." PLoS One, vol. 7, no. 1, 2012. https://doi.org/10.1371/journal.pone.0029803

Filipović, Boris, Ivica Matak, Lidija Bach Rojecky and Zdravko Lacković. "Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy." PLoS One 7, no. 1 (2012). https://doi.org/10.1371/journal.pone.0029803

Filipović, B., et al. (2012) 'Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy', PLoS One, 7(1). doi: 10.1371/journal.pone.0029803

Filipović B, Matak I, Bach Rojecky L, Lacković Z. Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy. PLoS One [Internet]. 2012 January 04 [cited 2024 December 01];7(1). doi: 10.1371/journal.pone.0029803

B. Filipović, I. Matak, L. Bach Rojecky and Z. Lacković, "Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy", PLoS One, vol. 7, no. 1, January 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:385498. [Accessed: 01 December 2024]

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Metadata
Title (english)Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy
AuthorBoris Filipović
AuthorIvica Matak
AuthorLidija Bach-Rojecky
AuthorZdravko Lacković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
BACKGROUND: Infraorbital nerve constriction (IoNC) is an experimental model of trigeminal neuropathy. We investigated if IoNC is accompanied by dural extravasation and if botulinum toxin type A (BoNT/A) can reduce pain and dural extravasation in this model. ----- METHODOLOGY/PRINCIPAL FINDINGS: Rats which developed mechanical allodynia 14 days after the IoNC were injected with BoNT/A (3.5 U/kg) into vibrissal pad. Allodynia was tested by von Frey filaments and dural extravasation was measured as colorimetric absorbance of Evans blue - plasma protein complexes. Presence of dural extravasation was also examined in orofacial formalin-induced pain. Unilateral IoNC, as well as formalin injection, produced bilateral dural extravasation. Single unilateral BoNT/A injection bilaterally reduced IoNC induced dural extravasation, as well as allodynia (lasting more than 2 weeks). Similarly, BoNT/A reduced formalin-induced pain and dural extravasation. Effects of BoNT/A on pain and dural extravasation in IoNC model were dependent on axonal transport through sensory neurons, as evidenced by colchicine injections (5 mM, 2 µl) into the trigeminal ganglion completely preventing BoNT/A effects. ----- CONCLUSIONS/SIGNIFICANCE: Two different types of pain, IoNC and formalin, are accompanied by dural extravasation. The lasting effect of a unilateral injection of BoNT/A in experimental animals suggests that BoNT/A might have a long-term beneficial effect in craniofacial pain associated with dural neurogenic inflammation. Bilateral effects of BoNT/A and dependence on retrograde axonal transport suggest a central site of its action.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS One
Numberingvol. 7, no. 1, e29803
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0029803
URN:NBNurn:nbn:hr:105:385498
Publication2012-01-04
Document URLhttps://doi.org/10.1371/journal.pone.0029803
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:16:26