Lifestyle habits and the risk of head and neck cancer in Zagreb region

Scientific paper - Original scientific paper

• Title (croatian): Životne navike i rizik za rak glave i vrata u Zagrebačkoj regiji
• Author: Ariana Znaor
• Author: Mišo Virag
• Author: Tin Znaor
• Author: Spomenka Manojlović
• Author: Rajko Kušec
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

In 2002, International Agency for Research on Cancer launched a multicentric case-control study of head and neck cancer in 15 centres in 11 European countries, Croatia included. The Alcohol-related Cancers and Genetic Susceptibility in Europe (ARCAGE) study database with approximately 2500 case-control pairs is currently the largest head and neck cancer patients database in Europe. The aim of the present study was to estimate the risk of smoking and alcohol consumption in head and neck cancer patients from Zagreb region recruited in scope of the ARCAGE study. The cases (45 males, 9 females) and the controls (37 males, 9 females) were recruited from University Hospital Dubrava and Merkur University Hospital. A blood sample and a lifestyle questionnaire were collected from all study subjects. Data were analysed by logistic regression analysis. The distribution of cases was: 43 oral, 9 pharyngeal and 2 laryngeal cancer cases. Ever-smokers had a 4-fold higher cancer risk (adjusted OR 4.3 (CI 1.20-15.4)) compared to never-smokers. The adjusted odds ratio for alcohol consumption more than once a week was 4.1 (CI 1.5-11.2). The results are in keeping with previously published data from other countries.

Abstract (croatian)

Međunarodna agencija za istraživanje raka 2002. godine započela je multicentrično slučaj-kontrola istraživanje raka
glave i vrata u 15 centara u 11 europskih država uključujući Hrvatsku. Baza podataka istraživanja ARCAGE s oko 2500
parova slučaj-kontrola trenutno je najveća baza podataka o bolesnicima od raka glave i vrata u Europi. Cilj ovog istra-
živanja bio je procijeniti rizik pušenja i konzumacije alkohola u bolesnika od raka glave i vrata iz zagrebačke regije
regrutiranih u okviru istraživanja ARCAGE. Slučajevi (45 muškaraca i 9 žena) i kontrole (37 muškaraca, 9 žena) regrutirani
su iz Klinčke bolnice Dubrava i Kliničke bolnice Merkur. Od svih ispitanika prikupljen je uzorak krvi i anketni
upitnik. Podaci su analizirani logističkom regresijom. Raspodjela slučajeva bila je: 43 slučaja raka usne šupljine, 9
ždrijela i 2 grkljana. Pušači su imali četverostruko veći rizik za rak glave i vrata od nepušača (OR 4,3 (CI 1,20–15,4)).
Prilagođeni odnos šansi za konzumaciju alkohola više od jednom tjedno bio je 4,1 (CI 1,5–11,2). Rezultati su u skladu s
prethodno objavljenim podacima iz drugih zemalja.

• Keywords (english): Alcohol Drinking/adverse effects; Croatia; Female; Fruit; Head and Neck Neoplasms/etiology; Humans; Life Style; Male; Middle Aged; Risk; Smoking/adverse effects; Vegetables
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 35, no. 4, pp. 1125-1128
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:202010
• Publication: 2011-12
• Document URL: https://hrcak.srce.hr/75618
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:25:29