Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty

Scientific paper - Original scientific paper

• Author: Melita Buljan
• Author: Damir Nemet
• Author: Branka Golubić-Ćepulić
• Author: Goran Bićanić
• Author: Branko Tripković
• Author: Domagoj Delimar
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

PURPOSE:

Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA). ----- METHODS:

Prospective randomised trials in which erythropoietin 15,000 IU was administered intravenously twice a week or 30,000 IU once a week (total 90,000 IU) combined with ferrous II sulphate (Ferro-Gradumet 2) orally and compared with Ferro-Gradumet 2 alone. ----- RESULTS:

Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients. ----- CONCLUSION:

We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.

• Keywords (english): Administration, Oral; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip/methods; Blood Transfusion, Autologous/methods; Drug Administration Schedule; Drug Therapy, Combination; Erythropoietin/administration & dosage; Female; Ferrous Compounds/administration & dosage; Hemoglobins/metabolism; Humans; Injections, Intravenous; Male; Middle Aged; Osteoarthritis, Hip/metabolism; Osteoarthritis, Hip/surgery; Preoperative Care; Recombinant Proteins
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: International Orthopaedics
• Numbering: vol. 36, no. 4, pp. 703-709
• p-ISSN: 0341-2695
• DOI: https://doi.org/10.1007/s00264-011-1367-7
• URN:NBN: urn:nbn:hr:105:792126
• Publication: 2012-04
• Document URL: https://doi.org/10.1007/s00264-011-1367-7
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:31:14