Virološka dijagnostika reemergentnih infekcija: virus dengue

Scientific paper - Review paper

• Title (english): Virology diagnosis of re-emergent infections: dengue virus
• Author: Tatjana Vilibić-Čavlek
• Author: Sunčanica Ljubin-Sternak
• Author: Andrea Babić-Erceg
• Author: Mario Sviben
• Author: Gordana Mlinarić-Galinović
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Dengue is acute viral disease transmitted to humans by Aedes mosquitoes (Ae. aegypti, Ae. albopictus). Dengue virus belongs to the family Flaviviridae, genus Flavivirus. There are four dengue virus serotypes (1-4) which are maintained endemically. The disease is endemic in tropical and subtropical areas between latitudes 35 degrees N and 35 degrees S. Infections may be asymptomatic or may produce a wide spectrum of diseases: non-specific febrile illness, dengue fever, dengue haemorrhagic fever or dengue shock syndrome. For the first time in Croatia, Ae. albopictus was registered in Zagreb in October 2004. In autumn 2005, additional records of Ae. albopictus presence were made in many places along the Adriatic coast. During 2007, two cases of imported dengue fever were reported in Croatia, after which similar imported cases appeared continually. In August 2010, the first autochthonous case of dengue fever was recorded on the peninsula Peljesac. Though Croatia is not endemic for dengue, the existence of a corresponding vector and a latent threat by imported dengue cases demand state-of-the-art and timely diagnostics. The most commonly used methods in laboratory diagnosis of dengue infections involve detection of viral RNA, antigen detection and serologic methods (detection of antibodies).

Abstract (croatian)

Dengue je akutna virusna bolest koju na čovjeka prenose komarci roda Aedes (Ae. aegypti, Ae. albopictus).
Uzročnik je virus porodice Flaviviridae, roda Flavivirus. Postoje četiri različita serotipa virusa dengue (1-4) koji se mogu
održavati u endemskim područjima svijeta. Bolest se većinom pojavljuje u tropskim i suptropskim krajevima između 35°
sjeverne i 35° južne geografske širine. Infekcija može biti asimptomatska ili se očitovati kao nespecifična febrilna bolest,
dengue groznica, dengue hemoragijska groznica te dengue šok sindrom. Prisutnost komarca Ae. albopictus dokazana je i u
Hrvatskoj. Prvi nalaz ovog komarca zabilježen je na području Zagreba u listopadu 2004. godine, a u jesen 2005. godine i u
brojnim mjestima duž jadranske obale. Tijekom 2007. godine u nas su dokazana dva importirana slučaja dengue groznice,
nakon čega su importirani slučajevi kontinuirano bilježeni. U kolovozu 2010. godine zabilježen je prvi slučaj autohtone
dengue groznice u Hrvatskoj, na poluotoku Pelješcu. Iako Hrvatska nije endemsko područje za dengu, prisutnost
odgovarajućeg vektora, kao i moguća opasnost od importiranih slučajeva dengue zahtijevaju suvremenu i pravodobnu dijagnostiku
ove bolesti. Dijagnostika virusa dengue najčešće se provodi detekcijom virusne RNK, detekcijom antigena te
serološkom dijagnostikom (dokaz specifičnih protutijela).

• Keywords (english): Aedes; Animals; Croatia/epidemiology; Dengue/diagnosis; Dengue/epidemiology; Dengue/transmission; Dengue Virus/isolation & purification; Humans; Insect Vectors; Reverse Transcriptase Polymerase Chain Reaction
• Language: croatian
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Liječnički vjesnik
• Numbering: vol. 134, no. 5-6, pp. 164-167
• p-ISSN: 0024-3477
• URN:NBN: urn:nbn:hr:105:923426
• Publication: 2012-05
• Document URL: http://lijecnicki-vjesnik.hlz.hr/lijecnicki-vjesnik/viroloska-dijagnostika-reemergentnih-infekcija-virus-dengue/
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:41:50