Quality of life of Croatian breast cancer patients receiving adjuvant treatment--comparison to long-term breast cancer survivors

Scientific paper - Original scientific paper

• Title (croatian): Kvaliteta života u bolesnice s rakom dojke koje primaju adjuvantnu terapiju - usporedba s bolesnicama koje su dugotrajno preživjele rak dojke
• Author: Jure Murgić
• Author: Željko Soldić
• Author: Dubravka Vrljić
• Author: Ivan Šamija
• Author: Iva Kirac
• Author: Ante Bolanča
• Author: Zvonko Kusić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Quality of life (QoL) is an important outcome in assessment of breast cancer treatment. Data comparing QoL after different adjuvant treatments and QoL data on long-term survivors are modest. The aim of this study was to compare QoL scores of patients receiving adjuvant treatment with long-term breast cancer survivors, and to correlate QoL scores with clinical data. Sixty patients were recruited for the study: 20 during adjuvant radiotherapy, 20 during adjuvant chemotherapy, and 20 long-term breast cancer survivors. QoL was assessed using the self-administered EORTC core questionnaire QLQ-C30 and breast cancer-specific module QLQ-BR23. QoL scores between groups were compared using Kruskal-Wallis test and effects of clinical factors on QoL domains were tested using multiple regression analysis. No differences between three groups were observed in terms of all QoL scores. As measured by QLQ-C30, least affected QoL scales were cognitive functioning, social functioning, and physical functioning in all three patients group, while insomnia and pain scales were the most detrimentally affected. Among the groups, the highest scores of global health status and other functional scales were in adjuvant chemotherapy group. Measured by QLQ-BR23, body image scale was most affected, while sexual functioning scale was minimally affected, in all three groups. Multiple regression analysis has shown that the patient age were the only statistically significant predictor for global health status scale, and constipation scale. Our results demonstrated similar and favorable QoL in all three groups of patients and provided basic information on QoL in Croatian breast cancer patients.

Abstract (croatian)

Kvaliteta života (KŽ) je važan detalj u procesu odlučivanju o načinu liječenja raka dojke. Podaci o usporedbi KŽ
nakon različitih oblika adjuvantnog liječenja i podataka o KŽ u bolesnica koje su dugotrajno preživjele rak dojke su
skromni. Cilj ovog istraživanja bio je usporediti kvantitativne vrijednosti domena KŽ bolesnica koji su primale adjuvantno
liječenje i bolesnica koje su dugotrajno preživjele rak dojke (koje su u praćenju) te povezati pojedine domene KŽ
sa kliničkim podacima. Šezdeset bolesnica je bilo uključeno u studiju: 20 za vrijeme adjuvantne radioterapije, 20 za
vrijeme adjuvantne kemoterapije i 20 bolesnica koje su dugotrajno preživjele rak dojke. KŽ je procijenjena primjenom
osnovnog EORTC upitnika QLQ-C30 i specifičnog modula za rak dojke QLQ-BR23. Bodovne vrijednosti KŽ uspoređene
su između skupina Kruskal-Wallis testom, a utjecaj kliničkih čimbenika na različite domene KŽ testiran je multiplom
regresijskom analizom. Nisu nađene razlike između tri skupine niti u jednoj od skala KŽ. Mjereno QLQ-C30 upitnikom,
najmanje pogođene skale KŽ su bile kognitivno funkcioniranje, socijalno funkcioniranje i tjelesno funkcioniranje u sve
tri skupine boesnica, dok su skale nesanice i bola bile najizraženije negativno pogođene. Među skupinama, najviše
bodovne vrijednosti općeg zdravstvenog statusa i drugih funkcijskih skala bile su u skupini bolesnica koje su primale
adjuvantnu kemoterapiju. Mjereno QLQ-BR23 upitnikom, skala predodžbe tijela bila je najviše pogođena dok je skala
seksualnog funkcioniranja bila najmanje pogođena u sve tri skupine. Multipla regresijska analiza pokazala je da je dob
bolesnica jedini statistički značajan prediktor za skalu općeg zdravstvenog statusa i skalu konstipacije. Naši rezultati
su pokazali sličnu i povoljnu KŽ u sve tri skupine bolesnica te su pružili osnovne informacije o KŽ u hrvatskih bolesnica
s rakom dojke.

• Keywords (english): Aged; Breast Neoplasms / psychology; Breast Neoplasms / therapy; Chemoradiotherapy, Adjuvant / psychology; Croatia; Female; Humans; Middle Aged; Quality of Life / psychology; Surveys and Questionnaires; Survivors / psychology; Time Factors
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 36, no. 4, pp. 1335-1341
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:122845
• Publication: 2012-12
• Document URL: https://hrcak.srce.hr/94917
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 19:44:37