prikaz prve stranice dokumenta Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate
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Scientific paper - Original scientific paper
Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate
Collegium Antropologicum, 37 (2013), 2; 471-476. urn:nbn:hr:105:355518
Bulum, Tomislav; Kolarić, Branko; Prkačin, Ingrid; Duvnjak, Lea

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Bulum, T., Kolarić, B., Prkačin, I. & Duvnjak, L. (2013). Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate . Collegium Antropologicum, 37. (2), 471-476. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:355518

Bulum, Tomislav, et al. "Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate ." Collegium Antropologicum, vol. 37, no. 2, 2013, pp. 471-476. https://urn.nsk.hr/urn:nbn:hr:105:355518

Bulum, Tomislav, Branko Kolarić, Ingrid Prkačin and Lea Duvnjak. "Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate ." Collegium Antropologicum 37, no. 2 (2013): 471-476. https://urn.nsk.hr/urn:nbn:hr:105:355518

Bulum, T., et al. (2013) 'Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate ', Collegium Antropologicum, 37(2), pp. 471-476. Available at: https://urn.nsk.hr/urn:nbn:hr:105:355518 (Accessed 08 November 2024)

Bulum T, Kolarić B, Prkačin I, Duvnjak L. Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate . Collegium Antropologicum [Internet]. 2013 June [cited 2024 November 08];37(2):471-476. Available at: https://urn.nsk.hr/urn:nbn:hr:105:355518

T. Bulum, B. Kolarić, I. Prkačin and L. Duvnjak, "Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate ", Collegium Antropologicum, vol. 37, no. 2, pp. 471-476, June 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:355518. [Accessed: 08 November 2024]

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Metadata
Title (english)Hyperfiltration in normoalbuminuric type 1 diabetic patients: relationship with urinary albumin excretion rate
Title (croatian)Utjecaj hiperfiltracije na razinu albumina u urinu u normoalbuminuričnih bolesnika s tipom 1 šećerne bolesti
AuthorTomislav Bulum
AuthorBranko Kolarić
AuthorIngrid Prkačin
AuthorLea Duvnjak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Hyperfiltration has been documented in type 1 diabetes and may contribute to the high risk for development of albuminuria and progression of nephropathy. However, recent studies suggest that the risk of progression to albuminuria in type 1 diabetes was not increased by hyperfiltration. We investigated associations of estimated glomerular filtration rate (eGFR) and urinary albumin excretion rate (UAE) in normoalbuminuric type 1 diabetic patients. Study included 313 normoalbuminuric patients with type 1 diabetes, none showed signs of adrenal, renal, or cardiovascular diseases. GFR was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Glomerular hyperfiltration was defined as eGFR > or = 125 mL min(-1) 1.73 m(-2). Renal hyperfiltration was present in 12% of the study group. Subjects with eGFR > or = 125 mL min(-1) 1.73 m(-2) were younger, had shorter duration of diabetes, lower levels of total and LDL cholesterol, and higher HbA1c than subjects with an eGFR below 125 mL min(-1) 1.73 m(-2). Type 1 diabetic patients with hyperfiltration also had significantly lower UAE. In a multiple logistic regression analysis, higher eGFR was associated with lower UAE. Our results indicate that normoalbuminuric type 1 diabetic patients with hyperfiltration have lower UAE than those with renal function in the normal range. Together with other recent studies this may suggest that creatinine-based estimates of GFR indicating hyperfiltration is not associated with higher UAE and subsequent development of microalbuminuria.
Abstract (croatian)
Glomerularna hiperfiltracija je česta kod bolesnika s tipom 1 šećerne bolesti i dugi niz godina je prepoznata kao rizični čimbenik razvoja mikro- i makroalbuminurije te nefropatije. Međutim, novije prospektivne studije na velikom broju ispitanika s tipom 1 šećerne bolesti nisu potvrdile da hiperfiltracija doprinosi razvoju mikroalbuminurije. Istraživali smo povezanost glomerularne filtracije (GF) i razine albumina u urinu u normoalbuminuričnih bolesnika s tipom 1 šećerne bolesti. U istraživanje je uključeno 313 bolesnika s tipom 1 šećerne bolesti koji nisu imali poremećaj funkcije nadbubrežne žlijezde, bubrežnu insuficijenciju ili kardiovaskularnu bolest. GF je izračunata prema Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formuli. Glomerularna hiperfiltracija je definirana kao vrijednost GF > ili = 125 mL min–1 1,73 m–2. Glomerularna hiperfiltracija je bila prisutna u 12% ispitanika. Ispitanici s GF > ili = 125 mL min–1 1,73 m–2 bili su mlađi, imali su kraće trajanje šećerne bolesti, nižu razinu ukupnog i LDL kolesterola te višu razinu HbA1c u odnosu na ispitanike s GF <125 mL min–1 1,73 m–2. Bolesnici s glomerularnom hiperfiltracijom su imali statistički značano nižu razinu albumina u urinu. Multiplom logističkom regresijom viša vrijednost GF bila je povezana s nižom razinom albumina u urinu. Rezultati našeg istraživanja ukazuju da je serumskim kreatininom izračunata glomerularna hiperfiltracija povezana s nižom razinom albumina u urinu u normoalbuminuričnih bolesnika s tipom 1 šećerne bolesti. Rezultati našeg istraživanja su u skladu s rezultatima novijih istraživanja koji ukazuju da glomerularna hiperfiltracija nije rizični čimbenik kasnijeg razvoja mikroalbuminurije u bolesnika s tipom 1 šećerne bolesti.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 37, no. 2, pp. 471-476
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:355518
Publication2013-06
Document URLhttps://hrcak.srce.hr/104485
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:49:30