prikaz prve stranice dokumenta Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy
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Scientific paper - Original scientific paper
Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy
Collegium Antropologicum, 37 (2013), 3; 777-782. urn:nbn:hr:105:081422
Bulum, Tomislav; Prkačin, Ingrid; Blaslov, Kristina; Zibar, Karin; Duvnjak, Lea

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Bulum, T., Prkačin, I., Blaslov, K., Zibar, K. & Duvnjak, L. (2013). Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy . Collegium Antropologicum, 37. (3), 777-782. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:081422

Bulum, Tomislav, et al. "Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy ." Collegium Antropologicum, vol. 37, no. 3, 2013, pp. 777-782. https://urn.nsk.hr/urn:nbn:hr:105:081422

Bulum, Tomislav, Ingrid Prkačin, Kristina Blaslov, Karin Zibar and Lea Duvnjak. "Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy ." Collegium Antropologicum 37, no. 3 (2013): 777-782. https://urn.nsk.hr/urn:nbn:hr:105:081422

Bulum, T., et al. (2013) 'Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy ', Collegium Antropologicum, 37(3), pp. 777-782. Available at: https://urn.nsk.hr/urn:nbn:hr:105:081422 (Accessed 14 July 2024)

Bulum T, Prkačin I, Blaslov K, Zibar K, Duvnjak L. Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy . Collegium Antropologicum [Internet]. 2013 September [cited 2024 July 14];37(3):777-782. Available at: https://urn.nsk.hr/urn:nbn:hr:105:081422

T. Bulum, I. Prkačin, K. Blaslov, K. Zibar and L. Duvnjak, "Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy ", Collegium Antropologicum, vol. 37, no. 3, pp. 777-782, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:081422. [Accessed: 14 July 2024]

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Metadata
Title (english)Association between red blood cell count and renal function exist in type 1 diabetic patients in the absence of nephropathy
Title (croatian)Povezanost između crvene slike i bubrežne funkcije je prisutna u bolesnika sa šećernom bolešću tipa 1 bez nefropatije
AuthorTomislav Bulum
AuthorIngrid Prkačin
AuthorKristina Blaslov
AuthorKarin Zibar
AuthorLea Duvnjak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Anemia is a prevalent finding in patients with type 1 diabetes, particularly in those with albuminuria or reduced renal function. We investigated the relationship between red blood cell count (RBC) and renal function in type 1 diabetic patients with normal or mildly impaired renal function and urinary albumin excretion rate (UAE) < 30 mg/24 h. Study included 313 type 1 diabetic patients with estimated glomerular filtration rate (eGFR) > 60 mL min(-1) 1.73 m(-2), and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. UAE was measured from at least two 24-h urine samples. Hemoglobin (Hb), hematocrit (Hct), erythrocytes (E), serum iron and ferritin levels were significantly lower in subjects in the highest quartile of serum creatinine compared to those in lowest quartile (132 vs 148 g/L, 0.39 vs 0.42 L/L, 4.5 vs 4.8 x 10(12)/L, 13 vs 18 micromol/L, and 25 vs 103 microg/L, respectively, for all p < 0.001). Hb and Hct levels were significantly lower in subjects in the highest quartile of UAE compared to those in lowest quartile (135 vs 140 g/L, and 0.40 vs 0.41 L/L, respectively, for all p = 0.03). Finally, those with mildly impaired eGFR had significantly lower levels of Hb, Hct and E compared to those with normal eGFR or hyperfiltrating subjects (133 vs 140 g/L, 0.38 vs 0.41 L/L, and 4.4 vs 4.7 x 10(12)/L, respectively, for all p = 0.01). We have detected that interplay between RBC and renal function parameters occurs even in type 1 diabetic patients with normal or mildly impaired renal function.
Abstract (croatian)
Anemija je česta u bolesnika sa tipom 1 šećerne bolesti, a posebno u onih s albuminurijom ili sniženom bubrežnom funkcijom. Istraživali smo povezanost crvene krvne slike i bubrežne funkcije u bolesnika s tipom 1 šećerne bolesti s normalnom ili blago sniženom bubrežnom funkcijom i razinom albumina u urinu (AU) <30 mg/24 h. Istraživanje je obuhvatilo 313 bolesnika sa tipom 1 šećerne bolesti s urednom ili blago sniženom glomerularnom filtracijom (GF >60 mL/min/1,73 m2), s AU <30 mg/24 h i bez terapije statinima, ACE-inhibitorima ili blokatorima angiotenzinskih receptora. Razina hemoglobina (Hb), hematokrita (Hct), eritrocita (E), serumskog željeza i feritina je bila značajno niža u bolesnika u najvišoj kvartili serumskog kreatinina u odnosu na one u najnižoj kvartili (132 vs 148 g/L, 0.39 vs 0,42 L/L, 4,5 vs 4,8x1012/L, 13 vs 18 μmol/L, i 25 vs 103 μg/L, p<0,001). Razina Hb i Hct je bila značajno niža u bolesnika u najvišoj kvartili AU u odnosu na one u najnižoj kvartili (135 vs 140 g/L, i 0,40 vs 0,41 L/L, p=0,03). Bolesnici s blago sniženom GF su imali značajno nižu razinu Hb, Hct i E u odnosu na one s urednom GF ili hiperfiltracijom (133 vs 140 g/L, 0,38 vs 0,41 L/L, i 4.4 vs 4,7x1012/L, p=0,01). Rezultati istraživanja ukazuju da povezanost crvene krvne slike i bubrežne funkcije postoji već u bolesnika s tipom 1 šećerne bolesti s normalnom ili blago sniženom bubrežnom funkcijom te AU <30 m/24 h.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 37, no. 3, pp. 777-782
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:081422
Publication2013-09
Document URLhttps://hrcak.srce.hr/118217
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:12:45