prikaz prve stranice dokumenta Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis
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Scientific paper - Original scientific paper
Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis
Antimicrobial Agents and Chemotherapy, 59 (2015), 6; 3084-3089. https://doi.org/10.1128/AAC.05016-14
Erdem, Hakan; Cag, Yasemin; Ozturk-Engin, Derya; Defres, Sylviane; Kaya, Selcuk; Larsen, Lykke; Poljak, Mario; Baršić, Bruno; Argemi, Xavier; Sørensen, Signe Maj; Bohr, Anne Lisbeth; Tattevin, Pierre; Gunst, Jesper Damsgaard; Baštáková, Lenka; Jereb, Matjaž; Johansen, Isik Somuncu; Karabay, Oguz; Pekok, Abdullah Umut; Sipahi, Oguz Resat; Chehri, Mahtab; Beraud, Guillaume; Shehata, Ghaydaa; Del Vecchio, Rosa Fontana; Maresca, Mauro; Karsen, Hasan; Sengoz, Gonul; Sunbul, Mustafa; Yilmaz, Gulden; Yilmaz, Hava; Sharif-Yakan, Ahmad; Kanj, Souha Shararah; Parlak, Emine; Pehlivanoglu, Filiz; Korkmaz, Fatime; Komur, Suheyla; Kose, Sukran; Ulug, Mehmet; Bolukcu, Sibel; Coskuner, Seher Ayten; Ince, Nevin; Akkoyunlu, Yasemin; Halac, Gulistan; Sahin-Horasan, Elif; Tireli, Hulya; Kilicoglu, Gamze; Al-Mahdawi, Akram; Nemli, Salih Atakan; Inan, Asuman; Senbayrak, Seniha; Stahl, Jean Paul; Vahaboglu, Haluk More authors...

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Erdem, H., Cag, Y., Ozturk Engin, D., Defres, S., Kaya, S., Larsen, L. ... Vahaboglu, H. (2015). Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis. Antimicrobial Agents and Chemotherapy, 59. (6), 3084-3089. doi: 10.1128/AAC.05016-14

Erdem, Hakan, et al. "Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis." Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, 2015, pp. 3084-3089. https://doi.org/10.1128/AAC.05016-14

Erdem, Hakan, Yasemin Cag, Derya Ozturk Engin, Sylviane Defres, Selcuk Kaya, Lykke Larsen, Mario Poljak, et al. "Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis." Antimicrobial Agents and Chemotherapy 59, no. 6 (2015): 3084-3089. https://doi.org/10.1128/AAC.05016-14

Erdem, H., et al. (2015) 'Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis', Antimicrobial Agents and Chemotherapy, 59(6), pp. 3084-3089. doi: 10.1128/AAC.05016-14

Erdem H, Cag Y, Ozturk Engin D, Defres S, Kaya S, Larsen L, and sur.. Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis. Antimicrobial Agents and Chemotherapy [Internet]. 2015 [cited 2024 October 06];59(6):3084-3089. doi: 10.1128/AAC.05016-14

H. Erdem, et al., "Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis", Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3084-3089, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:370387. [Accessed: 06 October 2024]

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Metadata
Title (english)Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis
AuthorHakan Erdem
AuthorYasemin Cag
AuthorDerya Ozturk-Engin
AuthorSylviane Defres
AuthorSelcuk Kaya
AuthorLykke Larsen
AuthorMario Poljak
AuthorBruno Baršić
AuthorXavier Argemi
AuthorSigne Maj Sørensen
AuthorAnne Lisbeth Bohr
AuthorPierre Tattevin
AuthorJesper Damsgaard Gunst
AuthorLenka Baštáková
AuthorMatjaž Jereb
AuthorIsik Somuncu Johansen
AuthorOguz Karabay
AuthorAbdullah Umut Pekok
AuthorOguz Resat Sipahi
AuthorMahtab Chehri
AuthorGuillaume Beraud
AuthorGhaydaa Shehata
AuthorRosa Fontana Del Vecchio
AuthorMauro Maresca
AuthorHasan Karsen
AuthorGonul Sengoz
AuthorMustafa Sunbul
AuthorGulden Yilmaz
AuthorHava Yilmaz
AuthorAhmad Sharif-Yakan
AuthorSouha Shararah Kanj
AuthorEmine Parlak
AuthorFiliz Pehlivanoglu
AuthorFatime Korkmaz
AuthorSuheyla Komur
AuthorSukran Kose
AuthorMehmet Ulug
AuthorSibel Bolukcu
AuthorSeher Ayten Coskuner
AuthorNevin Ince
AuthorYasemin Akkoyunlu
AuthorGulistan Halac
AuthorElif Sahin-Horasan
AuthorHulya Tireli
AuthorGamze Kilicoglu
AuthorAkram Al-Mahdawi
AuthorSalih Atakan Nemli
AuthorAsuman Inan
AuthorSeniha Senbayrak
AuthorJean Paul Stahl
AuthorHaluk Vahaboglu
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAntimicrobial Agents and Chemotherapy
Numberingvol. 59, no. 6, pp. 3084-3089
p-ISSN0066-4804
DOIhttps://doi.org/10.1128/AAC.05016-14
URN:NBNurn:nbn:hr:105:370387
Publication2015
Document URLhttps://doi.org/10.1128/AAC.05016-14
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:10:41