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Scientific paper - Original scientific paper
Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls
Annals of Clinical Biochemistry, 52 (2015), 2; 220-225. https://doi.org/10.1177/0004563214544709
Zibar, Karin; Knežević Ćuća, Jadranka; Blaslov, Kristina; Bulum, Tomislav; Smirčić Duvnjak, Lea

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Zibar, K., Knežević Ćuća, J., Blaslov, K., Bulum, T. & Smirčić Duvnjak, L. (2015). Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls. Annals of Clinical Biochemistry, 52. (2), 220-225. doi: 10.1177/0004563214544709

Zibar, Karin, et al. "Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls." Annals of Clinical Biochemistry, vol. 52, no. 2, 2015, pp. 220-225. https://doi.org/10.1177/0004563214544709

Zibar, Karin, Jadranka Knežević Ćuća, Kristina Blaslov, Tomislav Bulum and Lea Smirčić Duvnjak. "Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls." Annals of Clinical Biochemistry 52, no. 2 (2015): 220-225. https://doi.org/10.1177/0004563214544709

Zibar, K., et al. (2015) 'Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls', Annals of Clinical Biochemistry, 52(2), pp. 220-225. doi: 10.1177/0004563214544709

Zibar K, Knežević Ćuća J, Blaslov K, Bulum T, Smirčić Duvnjak L. Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls. Annals of Clinical Biochemistry [Internet]. 2015 [cited 2024 August 19];52(2):220-225. doi: 10.1177/0004563214544709

K. Zibar, J. Knežević Ćuća, K. Blaslov, T. Bulum and L. Smirčić Duvnjak, "Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls", Annals of Clinical Biochemistry, vol. 52, no. 2, pp. 220-225, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:613406. [Accessed: 19 August 2024]

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Metadata
Title (english)Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls
AuthorKarin Zibar
AuthorJadranka Knežević Ćuća
AuthorKristina Blaslov
AuthorTomislav Bulum
AuthorLea Smirčić Duvnjak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: The role of glucagon-like peptide-1 (GLP-1) has become a new scientific interest in the field of pathophysiology of type 1 diabetes mellitus (T1DM), but the results of the published studies were contradictory. The aim of our study was therefore to measure fasting and postprandial GLP-1 concentrations in T1DM patients and in healthy controls and to examine the difference in those concentrations between the two groups of subjects. ----- METHODS: The cross-sectional study included 30 C-peptide negative T1DM patients, median age 37 years (20-59), with disease duration 22 years (3-45), and 10 healthy controls, median age 30 years (27-47). Fasting and postprandial total and active GLP-1 concentrations were measured by ELISA (ALPCO, USA). The data were statistically analysed by SPSS, and significance level was accepted at P < 0.05. ----- RESULTS: Both fasting total and active GLP-1 concentrations were significantly lower in T1DM patients (total 0.4 pmol/L, 0-6.4 and active 0.2 pmol/L, 0-1.9) compared with healthy controls (total 3.23 pmol/L, 0.2-5.5 and active 0.8 pmol/L, 0.2-3.6), P = 0.008 for total GLP-1 and P = 0.001 for active GLP-1. After adjustment for age, sex and body mass index, binary logistic regression showed that both fasting total and active GLP-1 remained significantly independently lower in T1DM patients (total GLP-1: OR 2.43, 95% CI 1.203-4.909 and active GLP-1: OR 8.73, 95% CI 1.472-51.787). ----- CONCLUSIONS: T1DM patients had independently lower total and active GLP-1 fasting concentrations in comparison with healthy people, which supports the potential therapeutic role of incretin therapy, along with insulin therapy, in T1DM patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleAnnals of Clinical Biochemistry
Numberingvol. 52, no. 2, pp. 220-225
p-ISSN0004-5632
DOIhttps://doi.org/10.1177/0004563214544709
URN:NBNurn:nbn:hr:105:613406
Publication2015
Document URLhttps://doi.org/10.1177/0004563214544709
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:14:54