Evaluation of sentinel node biopsy in oral carcinomas

Scientific paper - Original scientific paper

• Title (croatian): Evaluacija sentinel biopsije limfnih čvorova u oralnom karcinomu
• Author: Aleksandar Milenović
• Author: Mišo Virag
• Author: Predrag Knežević
• Author: Vanja Vučićević Boras
• Author: Karmen Trutin Ostović
• Author: Dragana Gabrić Pandurić
• Author: Mato Sušić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

It is still a matter of debate whether sentinel node biopsy might replace neck dissection in patients with clinically negative neck lymph nodes who suffer from oral squamous cell carcinoma. In 30 patients (26 male, 4 female, average age 59.4 years) with oral squamous cell carcinoma we performed ultrasound guided punction of the lymph nodes which were lymphoscintigraphically seen together with histopatological analysis of the dissected node. Sentinel lymph node was seen in 93% cases. By use of lymphoscintigraphy sentinel node was verified in 23 patients. Ultrasound guided punction showed presence of regional disease in 10% of cases, whereas sentinel biopsy revealed 23 of the converted necks. Histopathological findings were positive in 33% of our patients. The results of this study revealed that sentinel biopsy did not reveal 27% of the patients with positive neck histopathology. In conclusion, sentinel node biopsy should be performed in selective cases as in some localizations it is easier to perform neck dissection in comparison to the sentinel node biopsy.

Abstract (croatian)

Još uvijek nije poznato da li sentinel biopsija limfnih čvorova može zamijeniti disekciju vrata u bolesnika koji boluju
od karcinoma usne šupljine i imaju klinički negativne limfne čvorove na vratu. U 30 bolesnika oboljelih od oralnog
planocelularnog karcinoma (26 muškaraca i 4 žene, prosječne dobi od 59,4 godine) je napravljena punkcija limfnih
čvorova uz pomoć ultrazvuka koji su viđeni i limfoscintigrafski te uz patohistološku analizu diseciranih čvorova. Sentinel
limfni čvorovi su viđeni u 93% slučaja. Upotrebom limfoscintigrafije su sentinel pozitivni čvorovi verificirani u 23
pacijenta. Punkcija uz pomoć ultrazvuka je pokazala prisutnost regionalne bolesti u 10% slučajeva, dok su uz pomoć
sentinel biopsije otkrivena 23 konvertirana vrata. Patohistološki nalaz je bio pozitivan u 33% bolesnika. Rezultati ovog
istraživanja pokazuju kako se sentinel biopsijom nije otkrilo 27% bolesnika sa pozitivnim patohistološkim nalazom
limfnih čvorova vrata. Zaključno, sentinel biopsija limfnih čvorova se treba napraviti u izdvojenim slučajevima jer je na
nekim mjestima lakše napraviti disekciju vrata u odnosu na sentinel biopsiju limfnih čvorova.

• Keywords (english): Carcinoma, Squamous Cell/radionuclide imaging; Carcinoma, Squamous Cell/secondary; Carcinoma, Squamous Cell/surgery; Female; Humans; Lymphatic Metastasis/pathology; Lymphatic Metastasis/radionuclide imaging; Male; Middle Aged; Mouth Neoplasms/pathology; Mouth Neoplasms/radionuclide imaging; Mouth Neoplasms/surgery; Radionuclide Imaging; Sentinel Lymph Node Biopsy; Ultrasonography, Interventional
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 38, no. 1, pp. 279-282
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:231958
• Publication: 2014-03
• Document URL: https://hrcak.srce.hr/120913
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:18:07