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Scientific paper - Case study
The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis
Collegium Antropologicum, 39 (2015), 2; 441-445. urn:nbn:hr:105:540244
Biočić, Stanko; Jakšić Jurinjak, Sandra; Vincelj, Josip; Barić, Davor; Manojlović, Spomenka; Delić Brkljačić, Diana

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Biočić, S., Jakšić Jurinjak, S., Vincelj, J., Barić, D., Manojlović, S. & Delić Brkljačić, D. (2015). The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis . Collegium Antropologicum, 39. (2), 441-445. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:540244

Biočić, Stanko, et al. "The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis ." Collegium Antropologicum, vol. 39, no. 2, 2015, pp. 441-445. https://urn.nsk.hr/urn:nbn:hr:105:540244

Biočić, Stanko, Sandra Jakšić Jurinjak, Josip Vincelj, Davor Barić, Spomenka Manojlović and Diana Delić Brkljačić. "The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis ." Collegium Antropologicum 39, no. 2 (2015): 441-445. https://urn.nsk.hr/urn:nbn:hr:105:540244

Biočić, S., et al. (2015) 'The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis ', Collegium Antropologicum, 39(2), pp. 441-445. Available at: https://urn.nsk.hr/urn:nbn:hr:105:540244 (Accessed 11 May 2024)

Biočić S, Jakšić Jurinjak S, Vincelj J, Barić D, Manojlović S, Delić Brkljačić D. The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis . Collegium Antropologicum [Internet]. 2015 June [cited 2024 May 11];39(2):441-445. Available at: https://urn.nsk.hr/urn:nbn:hr:105:540244

S. Biočić, S. Jakšić Jurinjak, J. Vincelj, D. Barić, S. Manojlović and D. Delić Brkljačić, "The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis ", Collegium Antropologicum, vol. 39, no. 2, pp. 441-445, June 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:540244. [Accessed: 11 May 2024]

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Metadata
Title (english)The role of standard echocardiographic parameters in endomyocardial biopsy proven cardiac amyloidosis
Title (croatian)Uloga standardne ehokardiografije u amiloidozi srca dokazanoj biopsijom miokarda
AuthorStanko Biočić
AuthorSandra Jakšić Jurinjak
AuthorJosip Vincelj
AuthorDavor Barić
AuthorSpomenka Manojlović
AuthorDiana Delić Brkljačić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Primary light-chain (AL) amyloidosis is a plasma cell dyscrasia associated with the deposition of immunoglobulin-derived amyloid in multiple organs. In the heart, this results in an infiltrative cardiomyopathy, with increased left ventricular wall thickness, normal or decreased left ventricular (LV) cavity size and congestive heart failure. Cardiac involvement is a major determinant of prognosis of AL amyloidosis. We report a patient with cardiac amyloidosis proven by cardiac biopsy, and aim to point out at transthoracic echocardiography as the hallmark of diagnostics. Echocardiography revealed increased LV thickness at 20mm, impaired LV ejection fraction (EF) at 35%, enlarged atria, transmitral deceleration time at 156 ms and increased E/A ratio at 4.25. Early diagnosis and intervention can have a significant impact on the patient's response to treatment, especially when the underlying condition involves a malignancy or infiltrative disorder. Standard transthoracic echocardiography as a noninvasive diagnostic tool is valuable and has a significant role in diagnosis and prognosis.
Abstract (croatian)
Primarna amiloidoza je diskrazija plazma stanica sa depozitima amiloida u multiplim organima. U srcu, to rezultira infiltrativnom kardiomiopatijom, zadebljalih stijenki ventrikla, normalnim ili smanjenim šupljinama srca te zatajenjem srca. Zahvaćenost srca je najvažniji prognostički faktor amiloidoze. Prikazujemo pacijenticu u dobi od 52 godine sa biopsijom miokarda dokazanom amiloidozom srca, u cilju prepoznavanja važnosti i naglašavanja ehokardiografskih karakteristika amiloidoze srca te ehokardiografije kao temeljnog dijagnostičkog postupka. Amiloidozu srca karakterizira dijastolička disfunkcija zbog infiltracije miokarda amiloidom. Rano prepoznavanje može poboljšati prognozu bolesnika. Na amiloidozu srca treba posumnjati kod bolesnika sa progresivnom dispnejom, uz nedilatativnu kardiomiopatiju sa zadebljalim stijenkama ventrikla u ehokardiogramu te zabilježenom mikrovoltažom u EKG-u. Pravovremena dijagnoza ima odraza na bolesnikov odgovor na liječenje, osobito ako osnovno stanje uključuju malignitet ili infiltrativni poremećaj, stoga standardna transtorakalna ehokardiografija kao neinvanzivna dijagnostička metoda ima značajnu ulogu u dijagnostičkom postupku i prognozi bolest.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 39, no. 2, pp. 441-445
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:540244
Publication2015-06
Document URLhttps://hrcak.srce.hr/166097
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:29:44