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Scientific paper - Case study
Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature
Acta Reumatológica Portuguesa, 40 (2015), 2; 169-175. urn:nbn:hr:105:578591
Šukara, Goran; Barešić, Marko; Sentić, Mirna; Brčić, Luka; Anić, Branimir

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Šukara, G., Barešić, M., Sentić, M., Brčić, L. & Anić, B. (2015). Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature. Acta Reumatológica Portuguesa, 40. (2), 169-175. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:578591

Šukara, Goran, et al. "Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature." Acta Reumatológica Portuguesa, vol. 40, no. 2, 2015, pp. 169-175. https://urn.nsk.hr/urn:nbn:hr:105:578591

Šukara, Goran, Marko Barešić, Mirna Sentić, Luka Brčić and Branimir Anić. "Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature." Acta Reumatológica Portuguesa 40, no. 2 (2015): 169-175. https://urn.nsk.hr/urn:nbn:hr:105:578591

Šukara, G., et al. (2015) 'Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature', Acta Reumatológica Portuguesa, 40(2), pp. 169-175. Available at: https://urn.nsk.hr/urn:nbn:hr:105:578591 (Accessed 09 May 2024)

Šukara G, Barešić M, Sentić M, Brčić L, Anić B. Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature. Acta Reumatológica Portuguesa [Internet]. 2015 April [cited 2024 May 09];40(2):169-175. Available at: https://urn.nsk.hr/urn:nbn:hr:105:578591

G. Šukara, M. Barešić, M. Sentić, L. Brčić and B. Anić, "Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature", Acta Reumatológica Portuguesa, vol. 40, no. 2, pp. 169-175, April 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:578591. [Accessed: 09 May 2024]

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Metadata
Title (english)Catastrophic antiphospholipid syndrome associated with systemic lupus erythematosus treated with rituximab: case report and a review of the literature
AuthorGoran Šukara
AuthorMarko Barešić
AuthorMirna Sentić
AuthorLuka Brčić
AuthorBranimir Anić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Catastrophic antiphospholipid syndrome (CAPS) is a rare, acute, life-threatening form of antiphospholipid syndrome. In the last several decades there has been a significant improvement in the treatment of patients with CAPS, but the overall mortality is still very significant. The use of rituximab has been reported in the treatment of refractory cases of CAPS but the data are still scarce and inconclusive. We report a case of 47-year old male patient with long standing SLE and secondary APS who presented with acute thromboembolic incident (partial thrombosis of superior mesenteric artery). During the first week of his hospitalization he met the criteria for probable CAPS. He was treated with anticoagulants, glucocorticoids, intravenous immunoglobulins and systemic antibiotics. Finally he was treated with rituximab. There was no response to the implemented treatment and he eventually died. Autopsy showed evidence of small vessel thrombosis in the lung microvasculature. With this the criteria for definitive CAPS were fulfilled. To our knowledge, at present time, this is the first ever reported case of definitive CAPS associated with SLE treated with rituximab. There is a great need for further investigation to evaluate the effectiveness of rituximab in treatment of CAPS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Reumatológica Portuguesa
Numberingvol. 40, no. 2, pp. 169-175
p-ISSN0303-464X
URN:NBNurn:nbn:hr:105:578591
Publication2015-04
Document URLhttp://actareumatologica.pt/article_download.php?id=1093
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:37:12