prikaz prve stranice dokumenta Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes
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Scientific paper - Original scientific paper
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes
Croatian Medical Journal, 57 (2016), 3; 287-292. https://doi.org/10.3325/cmj.2016.57.287
Nikolić, Igor; Kukulj, Suzana; Samaržija, Miroslav; Jeleč, Vjekoslav; Žarak, Marko; Orehovec, Biserka; Taradi, Ida; Romić, Dominik; Kolak, Toni; Patrlj, Leonardo

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Nikolić, I., Kukulj, S., Samaržija, M., Jeleč, V., Žarak, M., Orehovec, B. ... Patrlj, L. (2016). Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes. Croatian Medical Journal, 57. (3), 287-292. doi: 10.3325/cmj.2016.57.287

Nikolić, Igor, et al. "Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes." Croatian Medical Journal, vol. 57, no. 3, 2016, pp. 287-292. https://doi.org/10.3325/cmj.2016.57.287

Nikolić, Igor, Suzana Kukulj, Miroslav Samaržija, Vjekoslav Jeleč, Marko Žarak, Biserka Orehovec, Ida Taradi, Dominik Romić, Toni Kolak and Leonardo Patrlj. "Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes." Croatian Medical Journal 57, no. 3 (2016): 287-292. https://doi.org/10.3325/cmj.2016.57.287

Nikolić, I., et al. (2016) 'Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes', Croatian Medical Journal, 57(3), pp. 287-292. doi: 10.3325/cmj.2016.57.287

Nikolić I, Kukulj S, Samaržija M, Jeleč V, Žarak M, Orehovec B, and sur.. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes. Croatian Medical Journal [Internet]. 2016 June [cited 2024 October 13];57(3):287-292. doi: 10.3325/cmj.2016.57.287

I. Nikolić, et al., "Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes", Croatian Medical Journal, vol. 57, no. 3, pp. 287-292, June 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:555478. [Accessed: 13 October 2024]

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Metadata
Title (english)Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes
AuthorIgor Nikolić
AuthorSuzana Kukulj
AuthorMiroslav Samaržija
AuthorVjekoslav Jeleč
AuthorMarko Žarak
AuthorBiserka Orehovec
AuthorIda Taradi
AuthorDominik Romić
AuthorToni Kolak
AuthorLeonardo Patrlj
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To assess the diagnostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in lung cancer (LC). We compared the ratios between healthy participants and all LC patients, as well patients with different pathohistological LC subtypes. ----- METHODS: We retrieved the data on neutrophil, lymphocyte, and platelet levels in 449 patients with different pathohistological LC subtypes (non-small cell LC, small-cell LC, atypical or metastatic LC, neuroendocrine, and sarcomatoid carcinoma) and 47 healthy controls. NLR and PLR were calculated by dividing the absolute number of neutrophils or platelets with the absolute number of lymphocytes. ----- RESULTS: There were significant differences in both NLR and PLR (P<0.001) between all LC patients and the control group, but there were no differences between patients with different LC subtypes. Reciever operating characteristics analysis for NLR showed the optimal cut-off value of 2.71, with a sensitivity of 77.05% and specificity of 87.23%. The optimal cut-off value for PLR was 182.31, with a sensitivity of 51.09% and specificity of 91.49%. ----- CONCLUSION: The results showed that the NLR and PLR may have added value in the early diagnosis of LC, but further research is needed to confirm these results.
Abstract (croatian)
Omjer neutrofila i limfocita te omjer trombocita i limfocita mogu pomoći u identifikaciji pacijenta s rakom pluća, ali ne i u razlikovanju različitih podtipova tumora ----- Cilj: Odrediti dijagnostičku vrijednost omjera neutrofila i limfocita (prema engl. neutrophil-to-lymphocyte ratio, NLR) i omjera trombocita i limfocita (prema engl. platelet-to-lymphocyte ratio, PLR) za otkrivanje raka pluća. Usporedili smo omjere između zdravih ispitanika i pacijenata s rakom pluća, kao i između pacijenata s različitim patohistološkim podtipovima raka pluća. ----- Postupci: Prikupili smo podatke o razinama neutrofila, limfocita i trombocita kod 449 pacijenata s različitim patohistološkim podtipovima raka pluća (rak pluća ne-malih stanica, rak pluća malih stanica, atipični ili metastatski rak pluća, neuroendokrini, i sarkomatoidni rak) i 47 zdravih kontrolnih ispitanika. Izračunali smo NLR i PLR tako što smo podijelili apsolutni broj neutrofila ili trombocita s apsolutnim brojem limfocita. ----- Rezultati: Pronašli smo značajne razlike kako u NLR tako i u PLR (P< 0,001) između svih pacijenata s rakom pluća i kontrolnih ispitanika, no nismo našli razlike između pacijenata s različitim patohistološkim podtipovima raka pluća. Analiza krivulje osjetljivosti (prema engl. receiver operating characteristics curve, ROC curve) za NLR pokazala je da je optimalna granična vrijednost 2,71, s osjetljivošću od 77,05% i specifičnošću od 87,23%. Optimalna granična vrijednost za PLR bila je 182,31, s osjetljivošću od 51,09% i specifičnošću od 91,49%. ----- Zaključak: Pokazali smo da NLR i PLR mogu poslužiti kao dodatni parametar u ranoj dijagnozi raka pluća, no ovakve rezultate potrebno je potvrditi daljnjim istraživanjima.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 57, no. 3, pp. 287-292
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2016.57.287
URN:NBNurn:nbn:hr:105:555478
Publication2016-06
Document URLhttps://doi.org/10.3325/cmj.2016.57.287
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:43:55