Akne u dječjoj dobi

master's thesis

• Title (english): Acne in childhood
• Author: Vanesa Muharemović
• Mentor: Zrinka Bukvić Mokos (mentor)
• Committee member: ALEKSANDRA BASTA-JUZBAŠIĆ (predsjednik povjerenstva)
• Committee member: Krešimir Kostović (član povjerenstva)
• Committee member: Zrinka Bukvić Mokos (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Dermatology); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Akne je kronična upalna dermatoza koja se najčešće javlja u adolescentnoj dobi. Ukoliko se pojavi do dvanaeste godine života ili do menarhe u djevojčica riječ je o akne dječje dobi. S obzirom na dob bolesnika razlikujemo sljedeće tipove akne dječje dobi: nenonatalnu akne, akne u dojenačkoj dobi, akne u srednjem djetinjstvu i preadolescentnu akne. Patofiziologija neonatalne akne nije u potpunosti razjašnjena, dok u ostalih tipova akne u djecetreba misliti na mogući hormonski poremećaj. Stoga se dijagnostički pristup temelji na endokrinološkoj obradi, što je posebice važno kod akne u srednjem djetinstvu. Prema težini kliničke slike razlikujemo tri oblika akne: acne comedonica, acne papulopustulosa i acne nodularis/acne conglobata. Terapija akne dječje dobi ovisi o dobi bolesnika i težini kliničke slike. Neonatalne akne obično nije potrebno liječiti osim neonatalne cefalične pustuloze gdje se primjenjuju lokalni azoli. Ostali oblici akne dječje dobi liječe se lokalnom primjenom benzoil peroksida, antibiotika i retinoida ili kombinacijom ovih lijekova,a u težim slučajevima primjenjuje se sustavna antibiotska terapija. U najtežim oblicima bolesti primjenjuje se sustavni izotretinoin. Lokalni retinoidi prvi su izbor u terapiji održavanja. Pravovremeno uvođenje odgovarajuće terapije te edukacija roditelja i djece temelj su za postizanje terapijskog uspjeha.

Abstract (english)

Acne is a chronic inflammatory dermatologic disorder commonly affecting adolescent population. If begins in childhood before twelfth year or before menarche in girls it is called acne in childhood. This group of acne patients may be categorized into the four clinical entities based on the time of onset: neonatal acne, infantile acne, mid-childhood acne and
preadolescent acne. Pathophysiology of neonatal acne is only partially understood, while other types of acne may be caused by underlying hormonal abnormalities that should be considered. Therefore, diagnostic approach is based on endocrinology processing which is very important for the mid-childhood acne. There are three basic clinical forms of acne: comedonal acne, papulopustular acne and nodular/conglobate acne. Therapeutic approach depends on the severity of the clinical presentation and the patient’s age. Neonatal acne doesn’t require the treatment except in case of neonatal cephalic pustulosis when topic azoles are used. Therapy of other types of acne consists of topical application of benzoyl peroxide, antibiotics and retinoids or their combination; while in severe forms systemic antibiotic therapy is applied. Isotretinoin is used in the most severe forms. Topical retinoids are the first choice of maintenance therapy. Timely administered therapy and education of parents and children are the foundation of reaching the therapeutic success.

• Keywords: akne dječje dobi; patofiziologija; liječenje.
• Keywords (english): acne in childhood; pathophysiology; treatment.
• Language: croatian
• URN:NBN: urn:nbn:hr:105:330736
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-08-09 08:57:30