Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients

Blaslov, Kristina; Bulum, Tomislav; Duvnjak, Lea

doi:10.1016/j.jdiacomp.2014.12.019

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Scientific paper - Original scientific paper

Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients

Journal of Diabetes and its Complications, 29 (2015), 3; 390-394. https://doi.org/10.1016/j.jdiacomp.2014.12.019

Blaslov, Kristina; Bulum, Tomislav; Duvnjak, Lea

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APA 6th Edition

Blaslov, K., Bulum, T. & Duvnjak, L. (2015). Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients. Journal of Diabetes and its Complications, 29. (3), 390-394. doi: 10.1016/j.jdiacomp.2014.12.019

MLA 8th Edition

Blaslov, Kristina, et al. "Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients." Journal of Diabetes and its Complications, vol. 29, no. 3, 2015, pp. 390-394. https://doi.org/10.1016/j.jdiacomp.2014.12.019

Chicago 17th Edition

Blaslov, Kristina, Tomislav Bulum and Lea Duvnjak. "Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients." Journal of Diabetes and its Complications 29, no. 3 (2015): 390-394. https://doi.org/10.1016/j.jdiacomp.2014.12.019

Harvard

Blaslov, K., Bulum, T. and Duvnjak, L. (2015) 'Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients', Journal of Diabetes and its Complications, 29(3), pp. 390-394. doi: 10.1016/j.jdiacomp.2014.12.019

Vancouver

Blaslov K, Bulum T, Duvnjak L. Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients. Journal of Diabetes and its Complications [Internet]. 2015 April [cited 2024 September 28];29(3):390-394. doi: 10.1016/j.jdiacomp.2014.12.019

IEEE

K. Blaslov, T. Bulum and L. Duvnjak, "Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients", Journal of Diabetes and its Complications, vol. 29, no. 3, pp. 390-394, April 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:603398. [Accessed: 28 September 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:603398

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Title (english)	Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients
Author	Kristina Blaslov
Author	Tomislav Bulum
Author	Lea Duvnjak
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	AIM: The pathophysiology of insulin resistance (IR) comprises a complex adipokine mediated cross-talk between white adipose tissue and other organs. Dipeptidyl peptidase-4 (DPP4) is protease recently proposed as a novel adipokine linked to IR. We aimed to assess the relationship between fasting serum DPP4 activityand IR in type 1 diabetic (T1DM) patients. ----- METHODS: A cross-sectional study comprised 44 T1DM patients aged >18 and <65years. IR was esimated using the equation for insulin sensitivity derived from euglycemic-hyperinsulinemic clamp studies-estimated glucose disposal rate (eGDR). DPP4 serum activity was determined spectrophotometrically as a rate of cleavage of 7-Amino-4-Methyl Coumarin (AMC) from H-Gly-Pro-AMC. ----- RESULTS: Patients were divided according to DPP4 activity tertiles (<25.40; ≥36.54 U/L). Fasting serum DPP4 activity was related to disease duration (p=0.012), systolic (p=0.009) and diastolic (p=0.047) blood pressure, waist circumference (p=0.037), urine albumin excretion (p=0.022) and conversely related to eGDR (p=0.004). The linear regression has shown that eGDR decreases for 0.203 mgkg(-1)min(-1) by each increase of serum DPP4 activity of 1 U/L (p<0.001) after adjustment for adjusted for age, gender, disease duration, albuminuria and the use of antihypertensives and statins. ----- CONCLUSION: Serum DPP4 activity is associated with IR in T1DM patients and it might play an important role in its pathophysiology.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Accepted version
Journal title	Journal of Diabetes and its Complications
Numbering	vol. 29, no. 3, pp. 390-394
p-ISSN	1056-8727
DOI	https://doi.org/10.1016/j.jdiacomp.2014.12.019
URN:NBN	urn:nbn:hr:105:603398
Publication	2015-04
Document URL	https://doi.org/10.1016/j.jdiacomp.2014.12.019
Type of resource	Text
Access conditions	Open access
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Created on	2024-03-28 08:54:13