Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes

Scientific paper - Original scientific paper

• Author: Lea Duvnjak
• Author: Kristina Blaslov
• Author: Marijana Vučić Lovrenčić
• Author: Jadranka Knežević Ćuća
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

AIMS:

We aimed to determine serum dipeptidyl peptidase-4 (DPP-4) activity in a group of persons with latent autoimmune diabetes in adults (LADA) and to compare it with persons with type 1, type 2 diabetes and healthy controls. -----

METHODS:

DPP-4 activity measurement was performed in 67 persons (21 with type 1, 26 type 2 and 19 with LADA) and 13 healthy age and gender matched controls. -----

RESULTS:

Persons with LADA showed highest DPP-4 activity among the study groups (32.71±3.55 vs 25.37±2.84 vs 18.57±2.54 vs 18.57±2.61U/L p<0.001). Mean glutamic acid autoantibody in persons with LADA was 164.32±86.28IU/mL. It correlated with DPP-4 activity (r=0.484, p=0.013). Furthermore, DPP-4 activity correlated with waist circumference (r=0.279, p=0.034) and glycated haemoglobin A1c (r=0.483, p<0.001), as well as with LDL cholesterol (r=0.854, p<0.001) and total daily insulin dose (r=0.397, p=0.001). In the multinomial regression analysis DPP-4 activity remained associated with both LADA (prevalence ratio 1.058 (1.012-1.287), p=0.001) and type 1 diabetes (prevalence ratio 1.506 (1.335-1.765), p<0.001) while it did not show an association with type 2 diabetes (prevalence ratio 0.942 (0.713-1.988), p=0.564). -----

CONCLUSIONS:

Persons with LADA express higher DPP-4 activity compared to persons with both type 1 and type 2 diabetes. The possible pathophysiological role of DPP-4 in the LADA pathogenesis needs to be further evaluated.

• Keywords (english): Adult; Autoantibodies/blood; Biomarkers/blood; Diabetes Mellitus, Type 1/enzymology; Diabetes Mellitus, Type 2/enzymology; Dipeptidyl Peptidase 4/blood; Female; Hemoglobin A, Glycosylated/metabolism; Humans; Latent Autoimmune Diabetes in Adults/enzymology; Male; Middle Aged
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Diabetes Research and Clinical Practice
• Numbering: vol. 121, pp. 119-126
• p-ISSN: 0168-8227
• DOI: https://doi.org/10.1016/j.diabres.2016.09.013
• URN:NBN: urn:nbn:hr:105:675979
• Publication: 2016-11
• Document URL: https://doi.org/10.1016/j.diabres.2016.09.013
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:55:32