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Scientific paper - Original scientific paper
Role of MYC in B cell lymphomagenesis
Genes, 8 (2017), 4; 115. https://doi.org/10.3390/genes8040115
Korać, Petra; Dotlić, Snježana; Matulić, Maja; Zajc Petranović, Matea; Dominis, Mara

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Korać, P., Dotlić, S., Matulić, M., Zajc Petranović, M. & Dominis, M. (2017). Role of MYC in B cell lymphomagenesis. Genes, 8. (4), 115. doi: 10.3390/genes8040115

Korać, Petra, et al. "Role of MYC in B cell lymphomagenesis." Genes, vol. 8, no. 4, 2017, p. 115. https://doi.org/10.3390/genes8040115

Korać, Petra, Snježana Dotlić, Maja Matulić, Matea Zajc Petranović and Mara Dominis. "Role of MYC in B cell lymphomagenesis." Genes 8, no. 4 (2017): 115. https://doi.org/10.3390/genes8040115

Korać, P., et al. (2017) 'Role of MYC in B cell lymphomagenesis', Genes, 8(4), p. 115. doi: 10.3390/genes8040115

Korać P, Dotlić S, Matulić M, Zajc Petranović M, Dominis M. Role of MYC in B cell lymphomagenesis. Genes [Internet]. 2017 April 04 [cited 2024 December 23];8(4):115. doi: 10.3390/genes8040115

P. Korać, S. Dotlić, M. Matulić, M. Zajc Petranović and M. Dominis, "Role of MYC in B cell lymphomagenesis", Genes, vol. 8, no. 4, p. 115, April 2017. [Online]. . [Accessed: 23 December 2024]

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Title (english)Role of MYC in B cell lymphomagenesis
AuthorPetra Korać
AuthorSnježana Dotlić
AuthorMaja Matulić
AuthorMatea Zajc Petranović
AuthorMara Dominis
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
B cell lymphomas mainly arise from different developmental stages of B cells in germinal centers of secondary lymphoid tissue. There are a number of signaling pathways that affect the initiation and development of B cell lymphomagenesis. The functions of several key proteins that represent branching points of signaling networks are changed because of their aberrant expression, degradation, and/or accumulation, and those events determine the fate of the affected B cells. One of the most influential transcription factors, commonly associated with unfavorable prognosis for patients with B cell lymphoma, is nuclear phosphoprotein MYC. During B cell lymphomagenesis, oncogenic MYC variant is deregulated through various mechanisms, such as gene translocation, gene amplification, and epigenetic deregulation of its expression. Owing to alterations of downstream signaling cascades, MYC-overexpressing neoplastic B cells proliferate rapidly, avoid apoptosis, and become unresponsive to most conventional treatments. This review will summarize the roles of MYC in B cell development and oncogenesis, as well as its significance for current B cell lymphoma classification. We compared communication networks within transformed B cells in different lymphomas affected by overexpressed MYC and conducted a meta-analysis concerning the association of MYC with tumor prognosis in different patient populations.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGenes
Numberingvol. 8, no. 4, p. 115
p-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes8040115
Publication2017-04-04
Document URLhttp://doi.org/10.3390/genes8040115
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:08:04