prikaz prve stranice dokumenta Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period
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Scientific paper - Original scientific paper
Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period
International Journal of Oral and Maxillofacial Surgery, 47 (2018), 3; 283-288. https://doi.org/10.1016/j.ijom.2017.09.005
Granić, Marko; Suton, Petar; Mueller, Danko; Čvrljević, Igor; Lukšić, Ivica

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Granić, M., Suton, P., Mueller, D., Čvrljević, I. & Lukšić, I. (2018). Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period. International Journal of Oral and Maxillofacial Surgery, 47. (3), 283-288. doi: 10.1016/j.ijom.2017.09.005

Granić, Marko, et al. "Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period." International Journal of Oral and Maxillofacial Surgery, vol. 47, no. 3, 2018, pp. 283-288. https://doi.org/10.1016/j.ijom.2017.09.005

Granić, Marko, Petar Suton, Danko Mueller, Igor Čvrljević and Ivica Lukšić. "Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period." International Journal of Oral and Maxillofacial Surgery 47, no. 3 (2018): 283-288. https://doi.org/10.1016/j.ijom.2017.09.005

Granić, M., et al. (2018) 'Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period', International Journal of Oral and Maxillofacial Surgery, 47(3), pp. 283-288. doi: 10.1016/j.ijom.2017.09.005

Granić M, Suton P, Mueller D, Čvrljević I, Lukšić I. Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period. International Journal of Oral and Maxillofacial Surgery [Internet]. 2018 March [cited 2024 October 31];47(3):283-288. doi: 10.1016/j.ijom.2017.09.005

M. Granić, P. Suton, D. Mueller, I. Čvrljević and I. Lukšić, "Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period", International Journal of Oral and Maxillofacial Surgery, vol. 47, no. 3, pp. 283-288, March 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:871066. [Accessed: 31 October 2024]

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Title (english)Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period
AuthorMarko Granić
AuthorPetar Suton
AuthorDanko Mueller
AuthorIgor Čvrljević
AuthorIvica Lukšić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Mucoepidermoid carcinoma (MEC) is the most common malignancy of the salivary glands. The clinical behaviour of MEC is largely unpredictable, ranging from indolent tumour growth to highly aggressive metastatic spread. The objective of this study was to determine the clinicopathological predictors of recurrence and survival in patients with head and neck MEC. The medical records of 64 patients who underwent surgical treatment for head and neck MEC between 1982 and 2010 were reviewed. The main outcome measures were disease-free survival (DFS) and overall survival (OS). Clinicopathological parameters evaluated were age, sex, anatomical subsite, histological grade, tumour stage, tumour size, adjuvant therapy, and nodal and margin status. For the entire cohort, the 5-year DFS was 82.8% and the 5-year OS was 67.2%. Histological grade and tumour subsite were statistically significant predictors of OS. Furthermore, tumour stage and nodal status were statistically significant predictors with respect to OS. Advanced tumour stage, high histological grade, submandibular/sublingual localization, and positive nodal status were independent predictors of the prognosis in patients with head and neck MEC. Further studies into the molecular biology of MEC are needed in order to provide new therapeutic strategies for patients with locally aggressive and highly metastatic carcinomas.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Journal of Oral and Maxillofacial Surgery
Numberingvol. 47, no. 3, pp. 283-288
p-ISSN0901-5027
DOIhttps://doi.org/10.1016/j.ijom.2017.09.005
URN:NBNurn:nbn:hr:105:871066
Publication2018-03
Document URLhttps://doi.org/10.1016/j.ijom.2017.09.005
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:15:31