prikaz prve stranice dokumenta Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
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Scientific paper - Original scientific paper
Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
Leukemia Research, 66 (2018); 89-95. https://doi.org/10.1016/j.leukres.2018.01.017
Lucijanić, Marko; Prka, Željko; Pejša, Vlatko; Štoos-Veić, Tajana; Lucijanić, Jelena; Kušec, Rajko

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Lucijanić, M., Prka, Ž., Pejša, V., Štoos Veić, T., Lucijanić, J. & Kušec, R. (2018). Prognostic implications of low transferrin saturation in patients with primary myelofibrosis. Leukemia Research, 66., 89-95. doi: 10.1016/j.leukres.2018.01.017

Lucijanić, Marko, et al. "Prognostic implications of low transferrin saturation in patients with primary myelofibrosis." Leukemia Research, vol. 66, 2018, pp. 89-95. https://doi.org/10.1016/j.leukres.2018.01.017

Lucijanić, Marko, Željko Prka, Vlatko Pejša, Tajana Štoos Veić, Jelena Lucijanić and Rajko Kušec. "Prognostic implications of low transferrin saturation in patients with primary myelofibrosis." Leukemia Research 66 (2018): 89-95. https://doi.org/10.1016/j.leukres.2018.01.017

Lucijanić, M., et al. (2018) 'Prognostic implications of low transferrin saturation in patients with primary myelofibrosis', Leukemia Research, 66, pp. 89-95. doi: 10.1016/j.leukres.2018.01.017

Lucijanić M, Prka Ž, Pejša V, Štoos Veić T, Lucijanić J, Kušec R. Prognostic implications of low transferrin saturation in patients with primary myelofibrosis. Leukemia Research [Internet]. 2018 March [cited 2024 May 03];66:89-95. doi: 10.1016/j.leukres.2018.01.017

M. Lucijanić, Ž. Prka, V. Pejša, T. Štoos Veić, J. Lucijanić and R. Kušec, "Prognostic implications of low transferrin saturation in patients with primary myelofibrosis", Leukemia Research, vol. 66, pp. 89-95, March 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:418058. [Accessed: 03 May 2024]

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Metadata
Title (english)Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
AuthorMarko Lucijanić
AuthorŽeljko Prka
AuthorVlatko Pejša
AuthorTajana Štoos-Veić
AuthorJelena Lucijanić
AuthorRajko Kušec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES: Transferrin saturation (TSAT) 20% or less is considered to represent functional iron deficiency in the context of malignant disease, phenomenon mediated through inflammatory changes of iron homeostasis. We aimed to investigate clinical and prognostic significance of low TSAT in patients with primary (PMF) and secondary myelofibrosis (SMF), malignant diseases characterized by strong inflammatory milieu. ----- METHODS: We retrospectively analyzed 87 patients with myelofibrosis and compared TSAT with disease specific parameters. ----- RESULTS: One-third of patients had TSAT ≤20%. Lower TSAT was significantly associated with Janus-kinase-2 (JAK2) mutation (P = 0.007), transfusion independency (P = 0.003), higher platelets (P = 0.004), lower mean-corpuscular-volume (P < 0.001), lower ferritin (P < 0.001), higher absolute-neutrophil-count (P = 0.027), lower absolute-lymphocyte-count (P = 0.041) and lower albumin (P = 0.018). PMF patients presenting with low TSAT (≤20%) experienced significantly shorter overall-survival (OS) (HR = 2.43; P = 0.017), whereas TSAT did not affect OS of SMF patients (HR = 1.48; P = 0.623). Low TSAT remained significantly associated with inferior OS in PMF in a series of multivariate Cox regression models comparing its properties to anemia, transfusion dependency, ferritin and Dynamic-International-Prognostic-System (DIPSS). ----- CONCLUSIONS: Low TSAT has detrimental effect on survival of PMF patients. This effect is independent of anemia and of ferritin levels that seem to be better at representing iron overload in PMF patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleLeukemia Research
Numberingvol. 66, pp. 89-95
p-ISSN0145-2126
DOIhttps://doi.org/10.1016/j.leukres.2018.01.017
URN:NBNurn:nbn:hr:105:418058
Publication2018-03
Document URLhttps://doi.org/10.1016/j.leukres.2018.01.017
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:19:12