Hemoglobin A1c i kvaliteta skrbi za oboljele od šećerne bolesti

Professional paper - Review paper

• Title (english): Hemoglobin A1c and the quality of diabetes care
• Author: Marijana Vučić Lovrenčić
• Author: Lea Smirčić Duvnjak
• Author: Dario Rahelić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Global diabetes epidemics is currently representing one of the most prominent medical and societal challenges. Hemoglobin A1c (HbA1c), a biochemical marker of an average blood glucose concentration has been used for more than 30 years as a clinical indicator of both diabetes treatment efficacy and the risk for development of complications. Recently, HbA1C was proposed as a diabetes diagnostic test as well. Regular monitoring of glycemic control and adjustment of therapy towards the recommended HbA1c-based treatment-goals is a pivotal request of contemporary diabetes care guidelines, as well as a quality indicator proclaimed by numerous national health-care-delivery systems. Standardized and attainable analytical methodology of high-quality and a good knowledge on determinants of biological variability, able to influence test results, are crucial elements for the confident clinical use of HbA1c. In this review, essential analytical and clinical aspects necessary for the reliable use of HbA1c results in diabetes care are concisely presented, together with the degree of Croatian laboratory and clinical practice harmonization with the relevant international standards.

Abstract (croatian)

Globalna epidemija šećerne bolesti jedan je od najvećih izazova suvremene medicine i društva u cjelini. Hemoglobin A1c (HbA1c), biokemijski biljeg prosječne glikemije, već se više od 30 godina rabi kao klinički pokazatelj uspješnosti liječenja i rizika od razvoja komplikacija šećerne bolesti. HbA1c je nedavno preporučen i kao dijagnostički test za šećernu bolest. Redovito praćenje kontrole glikemije i prilagođavanje terapije prema odgovarajućim ciljnim vrijednostima HbA1c ključni je zahtjev svih suvremenih dijabetoloških smjernica te pokazatelj kvalitete zdravstvene skrbi brojnih nacionalnih zdravstvenih sustava. Standardizirana, dostupna i kvalitetna analitička metodologija, uz dobro poznavanje bioloških čim­benika koji mogu utjecati na nalaze testa, presudni su za sigurnu kliničku primjenu HbA1c. U ovom pregledu sažeto su prikazani ključni analitički i klinički čimbenici nužni za pouzdanu uporabu nalaza HbA1c u skrbi za oboljele od šećerne bolesti te razina usklađenosti hrvatske laboratorijske i kliničke prakse s relevantnim međunarodnim standardima.

• Keywords (english): Biomarkers/blood; Blood Glucose/metabolism; Diabetes Mellitus/blood; Diabetes Mellitus/therapy; Disease Management; Glycated Hemoglobin A/metabolism; Humans; Quality of Health Care
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Liječnički vjesnik
• Numbering: vol. 137, no. 9-10, pp. 292-296
• p-ISSN: 0024-3477
• URN:NBN: urn:nbn:hr:105:896062
• Publication: 2015-09
• Document URL: http://lijecnicki-vjesnik.hlz.hr/lijecnicki-vjesnik/hemoglobin-a1c-i-kvaliteta-skrbi-za-oboljele-od-secerne-bolesti/
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 09:33:14