Infekcije slobodno - živućim amebama

master's thesis

• Title (english): Infections with free - living amoebas
• Author: Jurica Marković
• Mentor: Mario Sviben (mentor)
• Committee member: Godrana Mlinarić-Galinović (predsjednik povjerenstva)
• Committee member: Goran Tešović (član povjerenstva)
• Committee member: Mario Sviben (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Infectious Diseases); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Medical Microbiology

Abstract

Infekcije uzrokovane slobodno-živućim amebama nisu toliko učestale, no često su smrtonosne, kako u imunokompetentnih tako i u imunokompromitiranih pacijenata. Slobodno-živuće amebe svrstavamo u nekoliko rodova: Naegleria, Acanthamoeba, Balamuthia i Sappinia. Četiri različita klinička entiteta uvjetovana su ovim organizmima: PAM (primarni amebni meningoencefalitis), GAE (granulomatozni amebni encefalitis), AK (amebni keratitis) te diseminirana granulomatozna amebna bolest. PAM je uzrokovan slobodno-živućom amebom N. fowleri. Pretežito se javlja u imonokompetentne mlađe djece i odraslih, obično nakon kontakta sa slatkovodnom vodom. GAE je uzrokovan slobodno-živućim amebama iz roda Acanthamoeba te vrstama Balamuthia mandrillaris i Sappinia pedata. Uobičajeno se javlja u imunokompromitiranih pojedinaca. AK je uzrokovan slobodno-živućim amebama iz roda Acanthamoeba. Javlja se u imunokompetentnih, a predisponirajuće čimbenike za razvoj AK-a predstavljaju traume rožnice i nošenje kontaktnih leća uz, istodobno, slabiju higijenu oka. Diseminiranu granulomatoznu amebnu bolesti uzrokuju slobodno-živuće amebe roda Acanthamoeba i vrsta Balamuthia mandrillaris. Pretežito se javlja u imunokompetentnih osoba. Dijagnostika ovih infekcija često je zakašnjela iz razloga što se na infekcije uzrokovane ovim organizmima vrlo rijetko i pomišlja. Terapijski algoritmi koji postoje još uvijek su nedovoljno kvalitetno uspostavljeni.

Abstract (english)

Infections caused by free-living amoebae are not so frequent, but often fatal, in immunocompetent as well as in immunocompromised patients. Free-living amoebae could be classified into several different species: Naegleria, Acanthamoeba, Balamuthia and Sappinia. Four different clinical entities are caused by these organisms: PAM (primary amoebic meningoencephalitis), GAE (granulomatous amoebic encephalitis), AK (amoebic keratitis) and disseminated granulomatous amoebic disease. PAM is caused by a free-living amoeba N. fowleri. It usually affects immunocompetent young children and adults, usually after the contact with fresh water. GAE is caused by free-living amoebae from the genus Acanthamoeba and the species Balamuthia mandrillaris and Sappinia pedata. It usually occurs in immunocompromised individuals. AK is caused by free-living amoeba from the genus Acanthamoeba. It occurs in immunocompetent subjects. The predisposing factors for the AK development are corneal trauma and the wearing of contact lenses combined with the insufficient eye-hygiene. Disseminated granulomatous amoebic disease is caused by a free-living amoebae from the genus Acanthamoeba and the species Balamuthia mandrillaris. It usually affects immunocompetent individuals. The diagnosis of infections caused by free-living amoebae is often delayed. The main reason for late diagnosis is insufficient clinical awareness. The current therapeutic algorithms are not satisfactory.

• Keywords: PAM; GAE; AK; diseminirana granulomatozna amebna bolest
• Keywords (english): PAM; GAE; AK; disseminated granulomatous amoebic disease
• Language: croatian
• URN:NBN: urn:nbn:hr:105:141911
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-08-10 09:32:59