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Scientific paper - Review paper
Treatment approach to type 2 diabetes: past, present and future
World Journal of Diabetes, 9 (2018), 12; 209-219. https://doi.org/10.4239/wjd.v9.i12.209
Blaslov, Kristina; Naranđa, Fran Stjepan; Kruljac, Ivan; Pavlić Renar, Ivana

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Blaslov, K., Naranđa, F. S., Kruljac, I. & Pavlić Renar, I. (2018). Treatment approach to type 2 diabetes: past, present and future. World Journal of Diabetes, 9. (12), 209-219. doi: 10.4239/wjd.v9.i12.209

Blaslov, Kristina, et al. "Treatment approach to type 2 diabetes: past, present and future." World Journal of Diabetes, vol. 9, no. 12, 2018, pp. 209-219. https://doi.org/10.4239/wjd.v9.i12.209

Blaslov, Kristina, Fran Stjepan Naranđa, Ivan Kruljac and Ivana Pavlić Renar. "Treatment approach to type 2 diabetes: past, present and future." World Journal of Diabetes 9, no. 12 (2018): 209-219. https://doi.org/10.4239/wjd.v9.i12.209

Blaslov, K., et al. (2018) 'Treatment approach to type 2 diabetes: past, present and future', World Journal of Diabetes, 9(12), pp. 209-219. doi: 10.4239/wjd.v9.i12.209

Blaslov K, Naranđa FS, Kruljac I, Pavlić Renar I. Treatment approach to type 2 diabetes: past, present and future. World Journal of Diabetes [Internet]. 2018 December 15 [cited 2024 July 13];9(12):209-219. doi: 10.4239/wjd.v9.i12.209

K. Blaslov, F. S. Naranđa, I. Kruljac and I. Pavlić Renar, "Treatment approach to type 2 diabetes: past, present and future", World Journal of Diabetes, vol. 9, no. 12, pp. 209-219, December 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:972663. [Accessed: 13 July 2024]

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Metadata
Title (english)Treatment approach to type 2 diabetes: past, present and future
AuthorKristina Blaslov
AuthorFran Stjepan Naranđa
AuthorIvan Kruljac
AuthorIvana Pavlić Renar
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Type 2 diabetes mellitus (DM) is a lifelong metabolic disease, characterized by hyperglycaemia which gradually leads to the development and progression of vascular complications. It is recognized as a global burden disease, with substantial consequences on human health (fatality) as well as on health-care system costs. This review focuses on the topic of historical discovery and understanding the complexity of the disease in the field of pathophysiology, as well as development of the pharmacotherapy beyond insulin. The complex interplay of insulin secretion and insulin resistance developed from previously known "ominous triumvirate" to "ominous octet" indicate the implication of multiple organs in glucose metabolism. The pharmacological approach has progressed from biguanides to a wide spectrum of medications that seem to provide a beneficial effect on the cardiovascular system. Despite this, we are still not achieving the target treatment goals. Thus, the future should bring novel antidiabetic drug classes capable of acting on several levels simultaneously. In conclusion, given the raising burden of type 2 DM, the best present strategy that could contribute the most to the reduction of morbidity and mortality should be focused on primary prevention.
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleWorld Journal of Diabetes
Numberingvol. 9, no. 12, pp. 209-219
p-ISSN1948-9358
DOIhttps://doi.org/10.4239/wjd.v9.i12.209
URN:NBNurn:nbn:hr:105:972663
Publication2018-12-15
Document URLhttps://doi.org/10.4239/wjd.v9.i12.209
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:58:39