prikaz prve stranice dokumenta Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall
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Scientific paper - Original scientific paper
Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall
Brain Structure and Function, 223 (2018), 9; 3919-3943. https://doi.org/10.1007/s00429-018-1721-2
Žunić Išasegi, Iris; Radoš, Milan; Krsnik, Željka; Radoš, Marko; Benjak, Vesna; Kostović, Ivica

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Žunić Išasegi, I., Radoš, M., Krsnik, Ž., Radoš, M., Benjak, V. & Kostović, I. (2018). Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall. Brain Structure and Function, 223. (9), 3919-3943. doi: 10.1007/s00429-018-1721-2

Žunić Išasegi, Iris, et al. "Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall." Brain Structure and Function, vol. 223, no. 9, 2018, pp. 3919-3943. https://doi.org/10.1007/s00429-018-1721-2

Žunić Išasegi, Iris, Milan Radoš, Željka Krsnik, Marko Radoš, Vesna Benjak and Ivica Kostović. "Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall." Brain Structure and Function 223, no. 9 (2018): 3919-3943. https://doi.org/10.1007/s00429-018-1721-2

Žunić Išasegi, I., et al. (2018) 'Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall', Brain Structure and Function, 223(9), pp. 3919-3943. doi: 10.1007/s00429-018-1721-2

Žunić Išasegi I, Radoš M, Krsnik Ž, Radoš M, Benjak V, Kostović I. Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall. Brain Structure and Function [Internet]. 2018 December [cited 2024 December 20];223(9):3919-3943. doi: 10.1007/s00429-018-1721-2

I. Žunić Išasegi, M. Radoš, Ž. Krsnik, M. Radoš, V. Benjak and I. Kostović, "Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall", Brain Structure and Function, vol. 223, no. 9, pp. 3919-3943, December 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513929. [Accessed: 20 December 2024]

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Metadata
Title (english)Interactive histogenesis of axonal strata and proliferative zones in the human fetal cerebral wall
AuthorIris Žunić Išasegi
AuthorMilan Radoš
AuthorŽeljka Krsnik
AuthorMarko Radoš
AuthorVesna Benjak
AuthorIvica Kostović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Development of the cerebral wall is characterized by partially overlapping histogenetic events. However, little is known with regards to when, where, and how growing axonal pathways interact with progenitor cell lineages in the proliferative zones of the human fetal cerebrum. We analyzed the developmental continuity and spatial distribution of the axonal sagittal strata (SS) and their relationship with proliferative zones in a series of human brains (8-40 post-conceptional weeks; PCW) by comparing histological, histochemical, and immunocytochemical data with magnetic resonance imaging (MRI). Between 8.5 and 11 PCW, thalamocortical fibers from the intermediate zone (IZ) were initially dispersed throughout the subventricular zone (SVZ), while sizeable axonal "invasion" occurred between 12.5 and 15 PCW followed by callosal fibers which "delaminated" the ventricular zone-inner SVZ from the outer SVZ (OSVZ). During midgestation, the SS extensively invaded the OSVZ, separating cell bands, and a new multilaminar axonal-cellular compartment (MACC) was formed. Preterm period reveals increased complexity of the MACC in terms of glial architecture and the thinning of proliferative bands. The addition of associative fibers and the formation of the centrum semiovale separated the SS from the subplate. In vivo MRI of the occipital SS indicates a "triplet" structure of alternating hypointense and hyperintense bands. Our results highlighted the developmental continuity of sagittally oriented "corridors" of projection, commissural and associative fibers, and histogenetic interaction with progenitors, neurons, and glia. Histogenetical changes in the MACC, and consequently, delineation of the SS on MRI, may serve as a relevant indicator of white matter microstructural integrity in the developing brain.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBrain Structure and Function
Numberingvol. 223, no. 9, pp. 3919-3943
p-ISSN1863-2653
DOIhttps://doi.org/10.1007/s00429-018-1721-2
URN:NBNurn:nbn:hr:105:513929
Publication2018-12
Document URLhttps://doi.org/10.1007/s00429-018-1721-2
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:06:06