prikaz prve stranice dokumenta Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation
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Scientific paper - Original scientific paper
Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation
Neuroscience Letters, 666 (2018); 111-119. https://doi.org/10.1016/j.neulet.2017.12.040
Kosi, Nina; Alić, Ivan; Salamon, Iva; Mitrečić, Dinko

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Kosi, N., Alić, I., Salamon, I. & Mitrečić, D. (2018). Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation. Neuroscience Letters, 666., 111-119. doi: 10.1016/j.neulet.2017.12.040

Kosi, Nina, et al. "Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation." Neuroscience Letters, vol. 666, 2018, pp. 111-119. https://doi.org/10.1016/j.neulet.2017.12.040

Kosi, Nina, Ivan Alić, Iva Salamon and Dinko Mitrečić. "Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation." Neuroscience Letters 666 (2018): 111-119. https://doi.org/10.1016/j.neulet.2017.12.040

Kosi, N., et al. (2018) 'Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation', Neuroscience Letters, 666, pp. 111-119. doi: 10.1016/j.neulet.2017.12.040

Kosi N, Alić I, Salamon I, Mitrečić D. Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation. Neuroscience Letters [Internet]. 2018 February 14 [cited 2024 May 02];666:111-119. doi: 10.1016/j.neulet.2017.12.040

N. Kosi, I. Alić, I. Salamon and D. Mitrečić, "Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation", Neuroscience Letters, vol. 666, pp. 111-119, February 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:289273. [Accessed: 02 May 2024]

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Metadata
Title (english)Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation
AuthorNina Kosi
AuthorIvan Alić
AuthorIva Salamon
AuthorDinko Mitrečić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Although transplantation of stem cells improves recovery of the nervous tissue, little is known about the influence of different brain regions on transplanted cells. After we confirmed that cells with uniform differentiation potential can be generated in independent experiments, one million of neural stem cells isolated from B6.Cg-Tg(Thy1-YFP)16Jrs/J mouse embryos were transplanted into the brain 24 h after induction of stroke. The lateral ventricles, the corpus callosum and the striatum were tested. Two and four weeks after the transplantation, the cells transplanted in all three regions have been attracted to the ischemic core. The largest number of attracted cells has been observed after transplantation into the striatum. Their differentiation pattern and expression of neuroligin 1, SynCAM 1, postsynaptic density protein 95 and synapsin 1 followed the same pattern observed during in vitro cultivation and it did not differ among the tested regions. Differentiation pattern of the cells transplanted in the stroke-affected and healthy animals was the same. On the other hand, neural stem cells transplanted in the striatum of the animals affected by stroke exhibited significantly increased survival rates reaching 260 ± 19%, when compared to cells transplanted in their wild type controls. Surprisingly, improved survival two and four weeks after transplantation was not due to increased proliferation of the grafted cells and it was accompanied by decreased levels of activity of Casp3 (19.56 ± 3.1% in the stroke-affected vs. 30.14 ± 2.4% in healthy animals after four weeks). We assume that the decreased levels of Casp3 in cells transplanted near the ischemic region was linked to increased vasculogenesis, synaptogenesis, astrocytosis and axonogenesis detected in the host tissue affected by ischemia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleNeuroscience Letters
Numberingvol. 666, pp. 111-119
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2017.12.040
URN:NBNurn:nbn:hr:105:289273
Publication2018-02-14
Document URLhttps://doi.org/10.1016/j.neulet.2017.12.040
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:13:58