prikaz prve stranice dokumenta Effects of metabolic syndrome on arterial function in different age groups
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Scientific paper - Original scientific paper
Effects of metabolic syndrome on arterial function in different age groups
Journal of Hypertension, 36 (2018), 4; 824-833. https://doi.org/10.1097/HJH.0000000000001631
Topouchian, Jirar; Labat, Carlos; Gautier, Sylvie; Bäck, Magnus; Achimastos, Apostolos; Blacher, Jacques; Cwynar, Marcin; de la Sierra, Alejandro; Pall, Denes; Fantin, Francesco; Farkas, Katalin; Garcia-Ortiz, Luis; Hakobyan, Zoya; Jankowski, Piotr; Jelaković, Ana; Kobalava, Zhanna; Konradi, Alexandra; Kotovskaya, Yulia; Kotsani, Marina; Lazareva, Irina; Litvin, Alexander; Milyagin, Viktor; Mintale, Iveta; Persson, Oscar; Ramos, Rafael; Rogoza, Anatoly; Ryliskyte, Ligita; Scuteri, Angelo; Sirenko, Yuriy; Soulis, Georges; Tasic, Nebojsa; Udovychenko, Maryna; Urazalina, Saule; Wohlfahrt, Peter; Zelveian, Parounak; Benetos, Athanase; Asmar, Roland More authors...

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Topouchian, J., Labat, C., Gautier, S., Bäck, M., Achimastos, A., Blacher, J. ... Asmar, R. (2018). Effects of metabolic syndrome on arterial function in different age groups. Journal of Hypertension, 36. (4), 824-833. doi: 10.1097/HJH.0000000000001631

Topouchian, Jirar, et al. "Effects of metabolic syndrome on arterial function in different age groups." Journal of Hypertension, vol. 36, no. 4, 2018, pp. 824-833. https://doi.org/10.1097/HJH.0000000000001631

Topouchian, Jirar, Carlos Labat, Sylvie Gautier, Magnus Bäck, Apostolos Achimastos, Jacques Blacher, Marcin Cwynar, et al. "Effects of metabolic syndrome on arterial function in different age groups." Journal of Hypertension 36, no. 4 (2018): 824-833. https://doi.org/10.1097/HJH.0000000000001631

Topouchian, J., et al. (2018) 'Effects of metabolic syndrome on arterial function in different age groups', Journal of Hypertension, 36(4), pp. 824-833. doi: 10.1097/HJH.0000000000001631

Topouchian J, Labat C, Gautier S, Bäck M, Achimastos A, Blacher J, and sur.. Effects of metabolic syndrome on arterial function in different age groups. Journal of Hypertension [Internet]. 2018 April [cited 2024 September 29];36(4):824-833. doi: 10.1097/HJH.0000000000001631

J. Topouchian, et al., "Effects of metabolic syndrome on arterial function in different age groups", Journal of Hypertension, vol. 36, no. 4, pp. 824-833, April 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:865025. [Accessed: 29 September 2024]

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Metadata
Title (english)Effects of metabolic syndrome on arterial function in different age groups
AuthorJirar Topouchian
AuthorCarlos Labat
AuthorSylvie Gautier
AuthorMagnus Bäck
AuthorApostolos Achimastos
AuthorJacques Blacher
AuthorMarcin Cwynar
AuthorAlejandro de la Sierra
AuthorDenes Pall
AuthorFrancesco Fantin
AuthorKatalin Farkas
AuthorLuis Garcia-Ortiz
AuthorZoya Hakobyan
AuthorPiotr Jankowski
AuthorAna Jelaković
AuthorZhanna Kobalava
AuthorAlexandra Konradi
AuthorYulia Kotovskaya
AuthorMarina Kotsani
AuthorIrina Lazareva
AuthorAlexander Litvin
AuthorViktor Milyagin
AuthorIveta Mintale
AuthorOscar Persson
AuthorRafael Ramos
AuthorAnatoly Rogoza
AuthorLigita Ryliskyte
AuthorAngelo Scuteri
AuthorYuriy Sirenko
AuthorGeorges Soulis
AuthorNebojsa Tasic
AuthorMaryna Udovychenko
AuthorSaule Urazalina
AuthorPeter Wohlfahrt
AuthorParounak Zelveian
AuthorAthanase Benetos
AuthorRoland Asmar
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVE: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. ----- METHODS: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health & Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid-femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40-49, 50-59, 60-74, 75-90 years. In this report, we present the baseline data of this study. ----- RESULTS: Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P < 0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r = 0.06, P < 0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57 ± 0.06 vs. 8.65 ± 0.10, P < 0.001; CAVI: 8.34 ± 0.03 vs. 8.29 ± 0.04, P = 0.40; mean ± SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV. ----- CONCLUSION: This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF-PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Hypertension
Numberingvol. 36, no. 4, pp. 824-833
p-ISSN0263-6352
DOIhttps://doi.org/10.1097/HJH.0000000000001631
URN:NBNurn:nbn:hr:105:865025
Publication2018-04
Document URLhttp://doi.org/10.1097/HJH.0000000000001631
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:20:23