prikaz prve stranice dokumenta Biomarkers in chronic graft-versus-host disease: quo vadis?
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Scientific paper - Original scientific paper
Biomarkers in chronic graft-versus-host disease: quo vadis?
Bone Marrow Transplantation, 53 (2018), 7; 832-837. https://doi.org/10.1038/s41409-018-0092-x
Wolff, D.; Greinix, H.; Lee, S. J.; Gooley, T.; Paczesny, S.; Pavletic, S.; Hakim, F.; Malard, F.; Jagasia, M.; Lawitschka, A.; Hansen, J. A.; Pulanić, Dražen; Holler, E.; Dickinson, A.; Weissinger, E.; Edinger, M.; Sarantopoulos, S.; Schultz, K. R. More authors...

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Wolff, D., Greinix, H., Lee, S. J., Gooley, T., Paczesny, S., Pavletic, S. ... Schultz, K. R. (2018). Biomarkers in chronic graft-versus-host disease: quo vadis?. Bone Marrow Transplantation, 53. (7), 832-837. doi: 10.1038/s41409-018-0092-x

Wolff, D., et al. "Biomarkers in chronic graft-versus-host disease: quo vadis?." Bone Marrow Transplantation, vol. 53, no. 7, 2018, pp. 832-837. https://doi.org/10.1038/s41409-018-0092-x

Wolff, D., H. Greinix, S. J. Lee, T. Gooley, S. Paczesny, S. Pavletic, F. Hakim, et al. "Biomarkers in chronic graft-versus-host disease: quo vadis?." Bone Marrow Transplantation 53, no. 7 (2018): 832-837. https://doi.org/10.1038/s41409-018-0092-x

Wolff, D., et al. (2018) 'Biomarkers in chronic graft-versus-host disease: quo vadis?', Bone Marrow Transplantation, 53(7), pp. 832-837. doi: 10.1038/s41409-018-0092-x

Wolff D, Greinix H, Lee SJ, Gooley T, Paczesny S, Pavletic S, and sur.. Biomarkers in chronic graft-versus-host disease: quo vadis?. Bone Marrow Transplantation [Internet]. 2018 July [cited 2024 July 12];53(7):832-837. doi: 10.1038/s41409-018-0092-x

D. Wolff, et al., "Biomarkers in chronic graft-versus-host disease: quo vadis?", Bone Marrow Transplantation, vol. 53, no. 7, pp. 832-837, July 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:811224. [Accessed: 12 July 2024]

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Metadata
Title (english)Biomarkers in chronic graft-versus-host disease: quo vadis?
AuthorD. Wolff
AuthorH. Greinix
AuthorS. J. Lee
AuthorT. Gooley
AuthorS. Paczesny
AuthorS. Pavletic
AuthorF. Hakim
AuthorF. Malard
AuthorM. Jagasia
AuthorA. Lawitschka
AuthorJ. A. Hansen
AuthorDražen Pulanić
AuthorE. Holler
AuthorA. Dickinson
AuthorE. Weissinger
AuthorM. Edinger
AuthorS. Sarantopoulos
AuthorK. R. Schultz
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Biomarkers are increasingly used for diagnosis and treatment of transplant-related complications including the first biomarker-driven interventional trials of acute graft-versus-host disease (GvHD). In contrast, the development of biomarkers of chronic GvHD (cGvHD) has lagged behind due to a broader variety of manifestations, overlap with acute GvHD, a greater variation in time to onset and maximum severity, and lack of sufficient patient numbers within prospective trials. An international workshop organized by a North-American and European consortium was held in Marseille in March 2017 with the goal to discuss strategies for future biomarker development to guide cGvHD therapy. As a result of this meeting, two areas were prioritized: the development of prognostic biomarkers for subsequent onset of moderate/severe cGvHD, and in parallel, the development of qualified clinical-grade assays for biomarker quantification. The most promising prognostic serum biomarkers are CXCL9, ST2, matrix metalloproteinase-3, osteopontin, CXCL10, CXCL11, and CD163. Urine-proteomics and cellular subsets (CD4+ T-cell subsets, NK cell subsets, and CD19+CD21low B cells) represent additional potential prognostic biomarkers of cGvHD. A joint effort is required to verify the results of numerous exploratory trials before any of the potential candidates is ready for validation and subsequent clinical application.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBone Marrow Transplantation
Numberingvol. 53, no. 7, pp. 832-837
p-ISSN0268-3369
DOIhttps://doi.org/10.1038/s41409-018-0092-x
URN:NBNurn:nbn:hr:105:811224
Publication2018-07
Document URLhttp://doi.org/10.1038/s41409-018-0092-x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:21:12