prikaz prve stranice dokumenta Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence
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Scientific paper - Original scientific paper
Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence
Journal of Clinical Medicine, 9 (2019), 1; 38. https://doi.org/10.3390/jcm9010038
Mijiritsky, Eitan; Ferroni, Letizia; Gardin, Chiara; Peleg, Oren; Gultekin, Alper; Saglanmak, Alper; Delogu, Lucia Gemma; Mitrečić, Dinko; Piattelli, Adriano; Tatullo, Marco; Zavan, Barbara

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Mijiritsky, E., Ferroni, L., Gardin, C., Peleg, O., Gultekin, A., Saglanmak, A. ... Zavan, B. (2019). Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence. Journal of Clinical Medicine, 9. (1), 38. doi: 10.3390/jcm9010038

Mijiritsky, Eitan, et al. "Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence." Journal of Clinical Medicine, vol. 9, no. 1, 2019, p. 38. https://doi.org/10.3390/jcm9010038

Mijiritsky, Eitan, Letizia Ferroni, Chiara Gardin, Oren Peleg, Alper Gultekin, Alper Saglanmak, Lucia Gemma Delogu, et al. "Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence." Journal of Clinical Medicine 9, no. 1 (2019): 38. https://doi.org/10.3390/jcm9010038

Mijiritsky, E., et al. (2019) 'Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence', Journal of Clinical Medicine, 9(1), p. 38. doi: 10.3390/jcm9010038

Mijiritsky E, Ferroni L, Gardin C, Peleg O, Gultekin A, Saglanmak A, and sur.. Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence. Journal of Clinical Medicine [Internet]. 2019 December 23 [cited 2024 May 08];9(1):38. doi: 10.3390/jcm9010038

E. Mijiritsky, et al., "Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence", Journal of Clinical Medicine, vol. 9, no. 1, p. 38, December 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513104. [Accessed: 08 May 2024]

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Metadata
Title (english)Presence of ROS in inflammatory environment of peri-implantitis tissue: in vitro and in vivo human evidence
AuthorEitan Mijiritsky
AuthorLetizia Ferroni
AuthorChiara Gardin
AuthorOren Peleg
AuthorAlper Gultekin
AuthorAlper Saglanmak
AuthorLucia Gemma Delogu
AuthorDinko Mitrečić
AuthorAdriano Piattelli
AuthorMarco Tatullo
AuthorBarbara Zavan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Analyses of composition, distribution of cellular and extracellular matrix components, and molecular analysis of mitochondria related genes of bone loss in the presence of inflammatory environment in humans was the aim of the present project. As a human model we chose peri-implantitis. Morphological analyses were performed by means classical histological, immunohistochemical, and SEM (scanning electron miscroscopy) test. Gene expression analysis was performed to evaluate epithelium maturation, collagen fiber production, and genes related to mitochondrial activity. It was found that a well-defined keratinocyte epithelium was present on the top of all specimens; a distinct basal lamina was present, as well as desmosomes and autophagic processes related to the maturation of keratinocytes. Under this epithelium, a full inflammatory cell infiltrate was present for about 60% of the represented by plasma cells. Collagen type I fibers were present mainly in the form of fragmented cord tissue without cells. A different distribution of blood vessels was also present from the apical to the most coronal portion of the specimens. High levels of genes related to oxidative stress were present, as well as the activation of genes related to the loss of ability of osteogenic commitment of Mesenchymal stem cells into osteoblasts. Our study suggests that peri-implantitis lesions exhibit a well defined biological organization not only in terms of inflammatory cells but also on vessel and extracellular matrix components even if no difference in the epithelium is evident, and that the presence of reactive oxygen species (ROS) related to the inflammatory environment influences the correct commitment of Mesenchymal stem cells.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 9, no. 1, p. 38
p-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm9010038
URN:NBNurn:nbn:hr:105:513104
Publication2019-12-23
Document URLhttp://doi.org/10.3390/jcm9010038
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:41:27