prikaz prve stranice dokumenta Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.)
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Scientific paper - Original scientific paper
Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.)
Collegium Antropologicum, 32 (2008), S. 1; 99-103. urn:nbn:hr:105:908965
Kovačić, Sanja; Petrinec, Zdravko; Matašin, Željka; Gjurčević, Emil; Ivkić, Goran; Lovrenčić-Huzjan, Arijana; Šegvić-Klarić, Maja; Rumora, Lada; Pepeljnjak, Stjepan

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Kovačić, S., Petrinec, Z., Matašin, Ž., Gjurčević, E., Ivkić, G., Lovrenčić Huzjan, A. ... Pepeljnjak, S. (2008). Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.). Collegium Antropologicum, 32. (S. 1), 99-103. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:908965

Kovačić, Sanja, et al. "Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.)." Collegium Antropologicum, vol. 32, no. S. 1, 2008, pp. 99-103. https://urn.nsk.hr/urn:nbn:hr:105:908965

Kovačić, Sanja, Zdravko Petrinec, Željka Matašin, Emil Gjurčević, Goran Ivkić, Arijana Lovrenčić Huzjan, Maja Šegvić Klarić, Lada Rumora and Stjepan Pepeljnjak. "Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.)." Collegium Antropologicum 32, no. S. 1 (2008): 99-103. https://urn.nsk.hr/urn:nbn:hr:105:908965

Kovačić, S., et al. (2008) 'Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.)', Collegium Antropologicum, 32(S. 1), pp. 99-103. Available at: https://urn.nsk.hr/urn:nbn:hr:105:908965 (Accessed 13 July 2024)

Kovačić S, Petrinec Z, Matašin Ž, Gjurčević E, Ivkić G, Lovrenčić Huzjan A, and sur.. Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.). Collegium Antropologicum [Internet]. 2008 January [cited 2024 July 13];32(S. 1):99-103. Available at: https://urn.nsk.hr/urn:nbn:hr:105:908965

S. Kovačić, et al., "Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.)", Collegium Antropologicum, vol. 32, no. S. 1, pp. 99-103, January 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:908965. [Accessed: 13 July 2024]

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Metadata
Title (english)Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.)
AuthorSanja Kovačić
AuthorZdravko Petrinec
AuthorŽeljka Matašin
AuthorEmil Gjurčević
AuthorGoran Ivkić
AuthorArijana Lovrenčić-Huzjan
AuthorMaja Šegvić-Klarić
AuthorLada Rumora
AuthorStjepan Pepeljnjak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Nitric oxide (NO) has been implicated in the pathogenesis of migraine and treatment with its exogenous donor glyceryl trinitrate (GTN) represents widely accepted experimental "migraine model". In this study, glyceryl trinitrate was administered intraperitoneally to carps, serum nitrite and nitrate levels were determined, permeability of blood-brain barrier was investigated, and histological changes of brain tissue were analyzed. Serum nitrite and nitrate levels displayed characteristic biphasic pattern with moderate initial increase and maximal terminal increase, suggesting the GTN-induced endogenous NO synthesis. Increased permeability of the blood-brain barrier in GTN-treated animals was determined based on Evans blue capillary leakage into the brain tissue. Histological analysis revealed changes consistent with vasodilatation and oedema. Our study strongly supports the importance of the NO role in the pathogenesis of migraine attacks and increase in blood-brain barrier permeability during the attack. The study has also provided evidence that this mechanism of action is conserved to the lower vertebrate.
Abstract (croatian)
Dušik (II) oksid (NO) je impliciran u patogenezi migrene, a tretiranje njegovim egzogenim donorom gliceril trinitratom (GTN), predstavlja općenito prihvaćen eksperimetalni »model migrene«. U našem smo pokusu šarane tretirali s gliceril trinitratom intraperitonealno te smo odredili koncentraciju serumskih nitrita i nitrata, ispitali propusnost krvno-moždane barijere i analizirali histopatološke promjene u tkivu mozga. Koncentracija serumskih nitrita i nitrata imala je karakterističan bifazični obrazac s blagim inicijalnim i maksimalnim terminalnim povećanjem što sugerira GTN-induciranu endogenu NO sintezu. GTN-tretirane životinje su pokazale povećanu propusnost krvno-moždane barijere, što smo utvrdili na temelju istjecanja Evans blue boje u moždano tkivo. Histopatološkom analizom ustanovljene su promjene karakteristične za vazodilataciju i edem. Naše istraživanje snažno podupire važnu ulogu NO u patogenezi migrenskog napadaja, odnosno povećanje propusnosti krvno-moždane barijere u migrenskom napadaju. Ovo istraživanje također dokazuje da je ovaj mehanizam djelovanja konzerviran do nižih kralješnjaka i zbog toga ga možemo smatrati važnim.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. S. 1, pp. 99-103
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:908965
Publication2008-01
Document URLhttps://hrcak.srce.hr/24561
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:48:07