prikaz prve stranice dokumenta MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome
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Scientific paper - Case study
MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome
Collegium Antropologicum, 31 (2007), 3; 919-921. urn:nbn:hr:105:829457
Radaković, Branko; Šprem Goldštajn, Marina

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Radaković, B. & Šprem Goldštajn, M. (2007). MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome. Collegium Antropologicum, 31. (3), 919-921. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:829457

Radaković, Branko and Marina Šprem Goldštajn. "MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome." Collegium Antropologicum, vol. 31, no. 3, 2007, pp. 919-921. https://urn.nsk.hr/urn:nbn:hr:105:829457

Radaković, Branko and Marina Šprem Goldštajn. "MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome." Collegium Antropologicum 31, no. 3 (2007): 919-921. https://urn.nsk.hr/urn:nbn:hr:105:829457

Radaković, B. and Šprem Goldštajn, M. (2007) 'MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome', Collegium Antropologicum, 31(3), pp. 919-921. Available at: https://urn.nsk.hr/urn:nbn:hr:105:829457 (Accessed 21 August 2024)

Radaković B, Šprem Goldštajn M. MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome. Collegium Antropologicum [Internet]. 2007 September [cited 2024 August 21];31(3):919-921. Available at: https://urn.nsk.hr/urn:nbn:hr:105:829457

B. Radaković and M. Šprem Goldštajn, "MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome", Collegium Antropologicum, vol. 31, no. 3, pp. 919-921, September 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:829457. [Accessed: 21 August 2024]

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Metadata
Title (english)MTHFR C 677T mutation and 4G/5G PAI-1 polymorphism in patient with polycystic ovarian syndrome
AuthorBranko Radaković
AuthorMarina Šprem Goldštajn
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Combined oral contraceptives (Ocs) are the most commonly used androgen suppressors and the treatment of choice for menstrual dysfunction in women with polycystic ovarian syndrome (PCOs). Although OCs have remained popular due to their convenience and effectiveness, there have been continuing concerns about adverse effects. The OCs have long been known to incur and increased risk of venous thromboembolism especially in carriers of common inherited thromboembolic defects. Factor V Leiden, prothrombin factor G20210A polymorphism, MTHFR (C677T) mutation and 4G/5G polymorphism of the PAI-1 gene account for the majority of thromboembolic events in association with oral contraceptive use. The aim of the article is to present woman with unrecognized inherited thrombophilia who was treated with OCs due to PCOs signs.
Abstract (croatian)
Kombinirani oralni kontraceptivi su najčešće korišteni supresori androgena, i lijek izbora u terapiji poremećaja menstruacijskog ciklusa u žena s policističnim ovarijskim sindromom. Iako su kombinirani oralni kontraceptivi popularni zbog praktičnosti i učinkovitosti, postoji kontinuirana zabrinutost zbog neželjenih učinaka. Poznato je da kombinirani oralni kontraceptivi potiču i povećavaju rizik nastanka venskog tromboembolizma, posebice u nositeljica nasljednih tromboembolijskih defekata. Faktor V Leiden, polimorfizam protrombinskog faktora G20210A, mutacija MTHFR (C677T) i polimorfizam 4G/5G PAI-1gena povezani su s većinom tromboembolijskih dogadjaja u žena koje koriste oralnu hormonsku kontracepciju. Cilj ovog rada je prikazati ženu s neprepoznatom nasljednom trombofilijom, koja je liječena oralnim kontraceptivima zbog znakova policističnog ovarijskog sindroma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 31, no. 3, pp. 919-921
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:829457
Publication2007-09
Document URLhttps://hrcak.srce.hr/26908
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:53:06