Aberrant glycosylation of Igg heavy chain in multiple myeloma

Aurer, Igor; Lauc, Gordan; Dumić, Jerka; Rendić, Dubravko; Matišić, Danica; Miloš, Marija; Heffer-Lauc, Marija; Flogel, Mirna; Labar, Boris

Scientific paper - Original scientific paper

Aberrant glycosylation of Igg heavy chain in multiple myeloma

Collegium Antropologicum, 31 (2007), 1; 247-251. urn:nbn:hr:105:851262

Aurer, Igor; Lauc, Gordan; Dumić, Jerka; Rendić, Dubravko; Matišić, Danica; Miloš, Marija; Heffer-Lauc, Marija; Flogel, Mirna; Labar, Boris

Cite this document

APA 6th Edition

Aurer, I., Lauc, G., Dumić, J., Rendić, D., Matišić, D., Miloš, M. ... Labar, B. (2007). Aberrant glycosylation of Igg heavy chain in multiple myeloma. Collegium Antropologicum, 31. (1), 247-251. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:851262

MLA 8th Edition

Aurer, Igor, et al. "Aberrant glycosylation of Igg heavy chain in multiple myeloma." Collegium Antropologicum, vol. 31, no. 1, 2007, pp. 247-251. https://urn.nsk.hr/urn:nbn:hr:105:851262

Chicago 17th Edition

Aurer, Igor, Gordan Lauc, Jerka Dumić, Dubravko Rendić, Danica Matišić, Marija Miloš, Marija Heffer Lauc, Mirna Flogel and Boris Labar. "Aberrant glycosylation of Igg heavy chain in multiple myeloma." Collegium Antropologicum 31, no. 1 (2007): 247-251. https://urn.nsk.hr/urn:nbn:hr:105:851262

Harvard

Aurer, I., et al. (2007) 'Aberrant glycosylation of Igg heavy chain in multiple myeloma', Collegium Antropologicum, 31(1), pp. 247-251. Available at: https://urn.nsk.hr/urn:nbn:hr:105:851262 (Accessed 15 November 2024)

Vancouver

Aurer I, Lauc G, Dumić J, Rendić D, Matišić D, Miloš M, and sur.. Aberrant glycosylation of Igg heavy chain in multiple myeloma. Collegium Antropologicum [Internet]. 2007 March [cited 2024 November 15];31(1):247-251. Available at: https://urn.nsk.hr/urn:nbn:hr:105:851262

IEEE

I. Aurer, et al., "Aberrant glycosylation of Igg heavy chain in multiple myeloma", Collegium Antropologicum, vol. 31, no. 1, pp. 247-251, March 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:851262. [Accessed: 15 November 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:851262

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Metadata

Title (english)	Aberrant glycosylation of Igg heavy chain in multiple myeloma
Author	Igor Aurer
Author	Gordan Lauc
Author	Jerka Dumić
Author	Dubravko Rendić
Author	Danica Matišić
Author	Marija Miloš
Author	Marija Heffer-Lauc
Author	Mirna Flogel
Author	Boris Labar
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	Although the majority of eukaryotic proteins are glycosylated, there is a dearth of knowledge regarding protein sugar moieties and their changes in disease. Most multiple myeloma cases are characterized by production of monoclonal immunoglobulins (Ig). We studied galactosylation and sialylation of IgG heavy chains in 16 patients with IgG myeloma using lectin blotting and densitometry. In comparison to age and sex matched controls, galactosylation was reduced in multiple myeloma (median 317 vs. 362, range 153-410 vs. 309-447 relative units, p = 0.015, Student's t-test). Sialylation was stage dependent; samples from patients with stage IIA had lowest amounts of sialic acid, IIIA intermediate and IIIB highest (142.6 vs. 185.9 vs. 248.5 relative units, correlation coefficient r = 0.55). Both galactosylation and sialylation levels were independent of age, sex, treatment type, response to treatment, disease duration and IgG and b2 microglobulin concentration. These data indicate that multiple myeloma is characterized by aberrant immunoglobulin glycosylation.
Abstract (croatian)	Iako je većina eukariotskih proteina glikozilirana, nema puno podataka o šećerima vezanima na proteine niti o njihovim promjenama u pojedinim bolestima. Multipli mijelom je većinom karakteriziran stvaranjem monoklonskih imunoglobulina (Ig). Istraživali smo galaktozilaciju i sijalilaciju IgG teškog lanca u 16 bolesnika s IgG mijelomom koristeći specifično vezivanje lektina i denzitometriju. U usporedbi s kontrolama podjednake dobi i spola je u multiplom mijelomu smanjena galaktozilacija (medijan 317 naprema 362, raspon 153–410 naprema 309–447 relativnih jedinica, p=0.015 koristeći Studentov t-test). Sijalilacija je ovisila o stadiju. Najmanje sijalinske kiseline je nađeno u uzorcima bolesnika sa stadijem IIA, nešto više u onih s IIIA, a najviše u IIIB stadiju (142,6 naprema 185,9 naprema 248,5 relativnih jedinica, koeficijent korelacije r=0,55). Ni razina galaktozilacije niti sijalilacije nisu ovisile o dobi, spolu, vrsti liječenja, odgovoru na liječenje, trajanju bolesti, koncentraciji IgG ili β2 mikroglobulina. Ovi podaci ukazuju da je multipli mijelom karakteriziran poremećajem glikozilacije imunoglobulina.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Collegium Antropologicum
Numbering	vol. 31, no. 1, pp. 247-251
p-ISSN	0350-6134
URN:NBN	urn:nbn:hr:105:851262
Publication	2007-03
Document URL	https://hrcak.srce.hr/27277
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2024-03-28 10:56:59