prikaz prve stranice dokumenta Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment
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Scientific paper - Original scientific paper
Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment
Collegium Antropologicum, 30 (2006), 1; 175-179. urn:nbn:hr:105:963826
Begovac, Josip; Lisić, Miroslav; Lukas, Davorka; Maretić, Tomislav; Kniewald, Tihana; Nowotny, Thomas E.

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Begovac, J., Lisić, M., Lukas, D., Maretić, T., Kniewald, T. & Nowotny, T. E. (2006). Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment. Collegium Antropologicum, 30. (1), 175-179. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:963826

Begovac, Josip, et al. "Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment." Collegium Antropologicum, vol. 30, no. 1, 2006, pp. 175-179. https://urn.nsk.hr/urn:nbn:hr:105:963826

Begovac, Josip, Miroslav Lisić, Davorka Lukas, Tomislav Maretić, Tihana Kniewald and Thomas E. Nowotny. "Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment." Collegium Antropologicum 30, no. 1 (2006): 175-179. https://urn.nsk.hr/urn:nbn:hr:105:963826

Begovac, J., et al. (2006) 'Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment', Collegium Antropologicum, 30(1), pp. 175-179. Available at: https://urn.nsk.hr/urn:nbn:hr:105:963826 (Accessed 23 December 2024)

Begovac J, Lisić M, Lukas D, Maretić T, Kniewald T, Nowotny TE. Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment. Collegium Antropologicum [Internet]. 2006 March [cited 2024 December 23];30(1):175-179. Available at: https://urn.nsk.hr/urn:nbn:hr:105:963826

J. Begovac, M. Lisić, D. Lukas, T. Maretić, T. Kniewald and T. E. Nowotny, "Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment", Collegium Antropologicum, vol. 30, no. 1, pp. 175-179, March 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:963826. [Accessed: 23 December 2024]

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Metadata
Title (english)Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment
AuthorJosip Begovac
AuthorMiroslav Lisić
AuthorDavorka Lukas
AuthorTomislav Maretić
AuthorTihana Kniewald
AuthorThomas E. Nowotny
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We compared the survival of patients following the first AIDS event in Croatia from the period 1986-1996 to the period 1997-2000. A total of 72 (81.8%) out of 88 patients from 1986-1996 and 18 (32.1%) out of 56 from 1997-2000 died. Survival following the first AIDS-defining illness markedly improved in the period 1997-2000 compared to the period 1986-1996 (adjusted Hazard Ratio (HR) for patients surviving more than 6 months: 0.11, 95% confidence interval (95% CI) = 0.04-0.29). A CD4+ cell count of < 100 x 10(6)/L was an independent risk factor for patients surviving up to 2 years (adjusted HR = 1.96, 95% CI = 1.1-3.43, p = 0.02). Patients with tuberculosis or fungal infections had a longer survival when compared to other diagnosis (adjusted HR = 0.53, 95% CI = 0.32-0.90, p = 0.01). However, despite dramatic survival benefit of combination antiretroviral therapy, mortality at six months following the first AIDS event was similar in the two study periods and the one-year probability of death was still substantial (27.2%) in the period 1997-2000.
Abstract (croatian)
Usporedili smo preživljavanje bolesnika nakon dijagnoze AIDS-a u Hrvatskoj u razdoblju 1986–1996. g. s razdobljem 1997– 2000. g. 72 (81,8%) od 88 bolesnika iz 1986–1996. g. i 18 (32,1%) od 56 iz 1997–2000. g. je umrlo. Preživljavanje nakon prve AIDS-definirajuće bolesti se značajno poboljšalo u razdoblju 1997–2000 u odnosu na razdoblje 1986–1996 (prilagođeni omjer hazarda (HR) za bolesnike koji su preživjeli više od 6 mjeseci: 0,11, 95% CI: 0,04–0,29). Broj CD4+ limfocita < 100 x 10na6/L je također bio neovisni čimbenik preživljavanja za bolesnike koji su preživjeli 2 godine (prilagođeni HR=1,96, 95%CI=1,1–3,43, p=0,02). Bolesnici s tuberkulozom ili gljivičnom infekcijom imali su bolje preživljavanje u usporedbi s drugim dijagnozama (prilagođeni HR=0,53, 95%CI=0,32–0,90, p=0,01). Međutim, usprkos izrazito boljem preživljavanju zbog kombinirane antiretrovirusne terapije, smrtnost 6 mjeseci od AIDS-a je bila slična u oba razdoblja, a smrtnost nakon jedne godine od AIDS-a je bila još uvijek značajna (27,2%) u razdoblju 1997–2000.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 30, no. 1, pp. 175-179
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:963826
Publication2006-03
Document URLhttps://hrcak.srce.hr/8909
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:59:40